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gene 991 words KG: AIF1
Contents

AIF1 Gene

🧬 Gene Info
Gene SymbolAIF1
Functionencodes a calcium-binding cytoskeletal adaptor that is strongly enriched in microglia.
PathwaysAutophagy, Inflammasome, Mitophagy, Neuroinflammatory
Ensembl IDENSG00000240065
GeneCardsAIF1
Human Protein AtlasAIF1
Associated DiseasesAging, Als, Alzheimer, PARKINSON DISEASE
Known Drugs/Compoundsrapamycin
InteractionsACTB, AD, AGING, AMPK, AND, ARC
KG Connections464 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypothesesLX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

ACTB associated_with AIF1
IL1B inhibits AIF1
IL6 inhibits AIF1
CASP1 associated_with AIF1
ATG5 associated_with AIF1
GFAP associated_with AIF1
SNCA inhibits AIF1
BECN1 associated_with AIF1
AIF1 associated_with ATG7
AIF1 inhibits ASC

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