gene

NEU1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEU1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

1Analyses

5Outgoing

3Incoming

0Experiments

1Debates

Summary

NEU1 Gene

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🧬 Gene Info

Gene Symbol	NEU1
Function	NEU1 encodes neuraminidase 1, also known as sialidase 1, a lysosomal enzyme that cleaves terminal sialic acid residues from glycoproteins, glycolipids, and oligosaccharides.
Primary Expression	neurons throughout the cortex, hippocampus, basal ganglia, and cerebellum
Subcellular Localization	and stability in the lysosome
Ensembl ID	ENSG00000105694
GeneCards	NEU1
Human Protein Atlas	NEU1
Glycoprotein degradation	Cleaving sialic acid residues to expose underlying sugars for further hydrolysis
Lysosomal function	Essential for proper lysosomal enzyme activity and autophagy
Cell surface remodeling	Modifying glycoconjugates on the cell surface
Immune regulation	Influencing immune cell function through modification of surface receptors
Liver	Highest expression
Brain	Neurons, astrocytes, microglia
Kidney	Tubular epithelial cells
Associated Diseases	neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NEU1 Gene

gene · 594 words

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Pathway Diagram

graph TD
    NEU1["NEU1"]
    Als["Als"]
    AIF1["AIF1"]
    HSPA1A["HSPA1A"]
    neurodegeneration["neurodegeneration"]

    NEU1 -->|"therapeutic target"| Als
    NEU1 -->|"associated with"| AIF1
    HSPA1A -->|"associated with"| NEU1
    NEU1 -->|"implicated in"| neurodegeneration

    style NEU1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Als fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style AIF1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style HSPA1A fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NEU1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
tau_aggregation	inhibits	mechanism	0.70
Als	therapeutic_target	disease	0.65
AIF1	associated_with	gene	0.60

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NEU1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
HSPA1A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

neurodegeneration | 2026-04-09 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning NEU1 in their description or question text

No additional research found