| Gene Symbol | STXBP1 |
| Full Name | Munc18-1 |
| Aliases | STXBP1PROTEIN |
| Protein Type | Protein |
| Function | is a neuronal protein essential for synaptic vesicle release and neurotransmitter secretion. |
| Primary Expression | non-neuronal tissues, important for immune function |
| Subcellular Localization | | Presynaptic terminal, cytosolic |
| Molecular Weight | 66 kDa |
| Amino Acids | 594 aa |
| UniProt ID | Search UniProt |
| GeneCards | STXBP1 |
| Human Protein Atlas | STXBP1 |
| Syntaxin Binding Sites | STXBP1 has multiple interaction surfaces for syntaxin-1, including the "front" surface (binding to Habc domain) and the "back" surface (binding to the N-terminal peptide of syntaxin) [2]. |
| Phosphorylation Sites | STXBP1 is phosphorylated at Ser306 by CDK5, which modulates its interaction with syntaxin and regulates synaptic vesicle priming [3]. |
| Dimerization Domain | STXBP1 can form dimers through its N-terminal domain, which may regulate its synaptic localization [4]. |
| Associated Diseases | ALS, neurodegeneration |
| Interactions | AND, DNAJC5, ERK, GENES, HSC70, MUNC18-1 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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