gene

GADD34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

10Outgoing

9Incoming

0Experiments

0Debates

Summary

GADD34 (Growth Arrest and DNA Damage Inducible Protein 34 / PPP1R15A) is a stress-induced gene that encodes a regulatory subunit of protein phosphatase 1, playing dual roles in stress recovery and apoptosis in neurodegeneration.

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🧬 Gene Info

Gene Symbol	GADD34
Aliases	Growth Arrest and DNA Damage Inducible Protein 34 / PPP1R15A
Chromosome	19q13.12
Protein Type	Phosphatase
Function	encodes a stress-induced regulatory subunit of protein phosphatase 1 (PP1) that plays a critical role in the integrated stress response (ISR).
Molecular Weight	81 kDa
Amino Acids	674 aa
Pathways	Apoptosis, Er Stress, Unfolded Protein Response
Ensembl ID	ENSG00000175319
GeneCards	GADD34
Human Protein Atlas	GADD34
PP1 binding	The RVxF motif mediates binding to PP1
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATF4, ATF6, DDIT3, ERN1, GENES, PERK
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GADD34["GADD34"]
    Als{"Als"}
    GADD34 -->|"activates"| Als
    XBP1["XBP1"]
    GADD34 -->|"activates"| XBP1
    Er_Stress(["Er Stress"])
    GADD34 -->|"activates"| Er_Stress
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    GADD34 -->|"activates"| Unfolded_Protein_Response
    Apoptosis(["Apoptosis"])
    GADD34 -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    GADD34 -->|"implicated in"| neurodegeneration
    ATF4["ATF4"]
    ATF4 -->|"activates"| GADD34
    DDIT3["DDIT3"]
    DDIT3 -->|"activates"| GADD34
    GENES["GENES"]
    GENES -->|"activates"| GADD34
    ERN1["ERN1"]
    ERN1 -->|"activates"| GADD34
    TREM2["TREM2"]
    TREM2 -->|"activates"| GADD34
    ATF6["ATF6"]
    ATF6 -->|"activates"| GADD34
    style GADD34 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
ALS	activates	disease	0.65
Apoptosis	activates	pathway	0.60
XBP1	activates	gene	0.60
PERK	activates	gene	0.60
Er Stress	activates	pathway	0.60
Unfolded Protein Response	activates	pathway	0.60
Fibroblast	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
genes-gadd34	documents	wiki_page	1.00
genes-gadd34	describes	wiki	0.90
GENES	activates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
ERN1	activates	gene	0.60
TREM2	activates	gene	0.60
ATF6	activates	gene	0.60
SOD1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GADD34 in their description or question text

No additional research found