gene

DNAJB9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

18Outgoing

10Incoming

0Experiments

0Debates

Summary

DNAJB9 is a gene implicated in neurodegeneration research. Key relationships include: protects against, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNAJB9
Full Name	DnaJ heat shock protein family (Hsp40) member B9
Chromosome	9p24.1
Function	is a member of the DnaJ heat shock protein family, which functions as a co-chaperone in the endoplasmic reticulum (ER).
Subcellular Localization	DNAJB9 is exclusively localized to the ER lumen, where it performs its chaperone functions. Its retention is mediated by
Molecular Weight	27 kDa
Amino Acids	292 aa
Exons	5
UniProt ID	[Q9Y3X0](https://www.uniprot.org/uniprot/Q9Y3X0)
Ensembl ID	ENSG00000102948
GeneCards	DNAJB9
Human Protein Atlas	DNAJB9
J domain function	Stimulates BiP ATPase activity
Substrate binding	Delivers folded/unfolding proteins to BiP
Allosteric regulation	Modulates BiP substrate affinity
Associated Diseases	Aging, Als
Interactions	HSPA1A, IL1A, Proteins
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNAJB9 Gene

gene · 2073 words

→

DNAJB9 Protein

protein · 1629 words

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Pathway Diagram

graph TD
    DNAJB9["DNAJB9"]
    Aging{"Aging"}
    DNAJB9 -->|"associated with"| Aging
    Als{"Als"}
    DNAJB9 -->|"associated with"| Als
    Ms{"Ms"}
    DNAJB9 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    DNAJB9 -->|"interacts with"| Carcinoma
    ALS{"ALS"}
    DNAJB9 -->|"associated with"| ALS
    Nf__b(["Nf-Kappab"])
    DNAJB9 -->|"associated with"| Nf__b
    HSPA1A["HSPA1A"]
    DNAJB9 -->|"associated with"| HSPA1A
    FN1["FN1"]
    DNAJB9 -->|"protects against"| FN1
    ERN1["ERN1"]
    DNAJB9 -->|"protects against"| ERN1
    PDIA6["PDIA6"]
    DNAJB9 -->|"protects against"| PDIA6
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    DNAJB9 -->|"interacts with"| Unfolded_Protein_Response
    AGING["AGING"]
    DNAJB9 -->|"associated with"| AGING
    HSPA1A -->|"associated with"| DNAJB9
    PECAM1["PECAM1"]
    PECAM1 -->|"protects against"| DNAJB9
    FOS["FOS"]
    FOS -->|"protects against"| DNAJB9
    FGF1["FGF1"]
    FGF1 -->|"protects against"| DNAJB9
    FGF5["FGF5"]
    FGF5 -->|"protects against"| DNAJB9
    IL1A["IL1A"]
    IL1A -->|"interacts with"| DNAJB9
    XBP1["XBP1"]
    XBP1 -->|"protects against"| DNAJB9
    AND["AND"]
    AND -->|"associated with"| DNAJB9
    AGING -->|"associated with"| DNAJB9
    style DNAJB9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
Age-Related Diseases	biomarker_for	disease	0.85
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Unfolded Protein Response	interacts_with	pathway	0.60
FN1	protects_against	gene	0.60
AGING	associated_with	gene	0.60
Interleukin	associated_with	protein	0.60
HSPA1A	regulates	gene	0.60
HSPA1A	upregulates	entity	0.60
PDIA6	protects_against	gene	0.60
HSPA1A	associated_with	gene	0.60
App	associated_with	protein	0.60
Nf-Κb	associated_with	pathway	0.60
ERN1	protects_against	gene	0.60
Proteins	activates	protein	0.50

Incoming (10)

Source	Relation	Type	Str
HSPA1A	associated_with	gene	0.60
PECAM1	protects_against	gene	0.60
FOS	protects_against	gene	0.60
FGF1	protects_against	gene	0.60
FGF5	protects_against	gene	0.60
IL1A	interacts_with	gene	0.60
XBP1	protects_against	gene	0.60
BGN	regulates	gene	0.60
AGING	associated_with	gene	0.60
HSPA1A	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJB9 in their description or question text

No additional research found