gene 559 words KG: XBP1
Contents

XBP1 — X-Box Binding Protein 1

🧬 Gene Info
Gene SymbolXBP1
Full NameX-Box Binding Protein 1
AliasesPage for XBP1
Chromosome22q12.1
Protein TypeTranscription Factor
FunctionER Expansion and Biogenesis: Increases ER membrane synthesis and volume
Primary ExpressionBrain, Liver, Pancreas, Immune cells
Molecular Weight29 kDa
Amino Acids261 aa
PathwaysAutophagy, Er Stress, Glycolysis, Mitophagy, Unfolded Protein Response
UniProt IDP17861
NCBI Gene ID7499
Ensembl IDENSG00000143419
GeneCardsXBP1
Human Protein AtlasXBP1
Associated DiseasesTumor
InteractionsAKT, AND, APOE4, ATF3, ATF4, ATF6
KG Connections261 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (13)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: activates
ATF3 Gene
gene · KG edge: activates
ATF4 Gene
gene · KG edge: activates
ATF6 - Activating Transcription Factor 6
gene · KG edge: activates

Knowledge Graph (12 edges)

CXCL2 therapeutic_target XBP1
IL6 therapeutic_target XBP1
ATF4 activates XBP1
PPP1R15A activates XBP1
IL12B therapeutic_target XBP1
XBP1 therapeutic_target CXCL1
XBP1 activates DDIT3
XBP1 therapeutic_target CLDN5
XBP1 activates HSPA5
XBP1 therapeutic_target OCLN

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.