protein

PAX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

27Outgoing

16Incoming

0Experiments

0Debates

Summary

PAX6 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, inhibits. Associated with Als, Glioblastoma, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PAX6
Full Name	Paired Box 6
Chromosome	11p13
Protein Family	Paired Box (PAX) Transcription Factor Family
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Developing eye, Brain (forebrain, cortex, hippocampus), Olfactory epithelium, Pancreas
Subcellular Localization	Nucleus
Molecular Weight	46.8 kDa
Amino Acids	128 aa
UniProt ID	P26367
Ensembl ID	ENSG00000061676
GeneCards	PAX6
Human Protein Atlas	PAX6
Associated Diseases	Alzheimer, neurodegeneration
Interactions	DNA, GFAP, Rb
KG Connections	43 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PAX6 — AlphaFold P26367 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PAX6 — Paired Box 6

gene · 630 words

→

PAX6 Protein

protein · 565 words

→

Pathway Diagram

graph TD
    PAX6["PAX6"]
    Ms{"Ms"}
    PAX6 -->|"regulates"| Ms
    Als{"Als"}
    PAX6 -->|"expressed in"| Als
    PAX6 -->|"expressed in"| Ms
    Glioblastoma{"Glioblastoma"}
    PAX6 -->|"expressed in"| Glioblastoma
    CDK6["CDK6"]
    PAX6 -->|"regulates"| CDK6
    Cell_Cycle(["Cell Cycle"])
    PAX6 -->|"inhibits"| Cell_Cycle
    ERN1["ERN1"]
    PAX6 -->|"expressed in"| ERN1
    FOXO1["FOXO1"]
    PAX6 -->|"expressed in"| FOXO1
    Neurogenesis(["Neurogenesis"])
    PAX6 -->|"expressed in"| Neurogenesis
    AND["AND"]
    PAX6 -->|"expressed in"| AND
    GENES["GENES"]
    PAX6 -->|"expressed in"| GENES
    DNA["DNA"]
    PAX6 -->|"inhibits"| DNA
    CDK6 -->|"regulates"| PAX6
    GENES -->|"expressed in"| PAX6
    DNA -->|"inhibits"| PAX6
    PBX3["PBX3"]
    PBX3 -->|"expressed in"| PAX6
    XBP1["XBP1"]
    XBP1 -->|"expressed in"| PAX6
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"expressed in"| PAX6
    style PAX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PAX6	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
corneal epithelial identity	mediates	phenotype	0.90
KRT12	regulates	gene	0.80
Ms	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.60
FOXO1	expressed_in	gene	0.60
Neurogenesis	expressed_in	pathway	0.60
SMARCA4	expressed_in	gene	0.60
SNAP25	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
ERN1	expressed_in	gene	0.60
neurodegeneration	associated_with	disease	0.60
GENES	expressed_in	gene	0.60
Rb	inhibits	protein	0.60
CDK6	regulates	gene	0.60
Cell Cycle	inhibits	pathway	0.60
Progenitor Cell	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
Cortex	expressed_in	brain_region	0.55
GENE EXPRESSION	regulates	concept	0.50
CELL CYCLE	activates	cell_type	0.50
CELL CYCLE	regulates	cell_type	0.50

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PAX6	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CD63	regulates	gene	0.85
DNA	inhibits	gene	0.60
CDK6	regulates	gene	0.60
NLGN2	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ADNP	expressed_in	gene	0.60
NLGN1	expressed_in	gene	0.60
GFAP	activates	gene	0.60
PBX3	expressed_in	gene	0.60
XBP1	expressed_in	gene	0.60
CDK6	expressed_in	entity	0.60
MICRORNAS	expressed_in	gene	0.60
HDAC3	co_expressed_with	gene	0.50
GFAP	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PAX6 in their description or question text

No additional research found