concept

MYELINATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYELINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

596Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MYELINATION is a concept in neurodegeneration research. Key relationships include: co discussed, impairs, expressed in. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 57 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MYELINATION
Key Genes/Proteins	APOE4

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oligodendrocytes in CNS Myelination

cell · 1109 words

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Pathway Diagram

graph TD
    MYELINATION["MYELINATION"]
    HDAC7["HDAC7"] -->|"regulates"| MYELINATION
    AQP4["AQP4"] -->|"activates"| MYELINATION
    CD19["CD19"] -->|"target for"| MYELINATION
    GPR37["GPR37"] -->|"inhibits"| MYELINATION
    CR2["CR2"] -->|"inhibits"| MYELINATION
    OVERVIEW["OVERVIEW"] -->|"inhibits"| MYELINATION
    SOD1["SOD1"] -->|"regulates"| MYELINATION
    GFAP["GFAP"] -->|"activates"| MYELINATION
    COMPLEMENT["COMPLEMENT"] -->|"causes"| MYELINATION

Outgoing (96)

Target	Relation	Type	Str
RNA	regulates	gene	0.60
SREBF2	regulates	gene	0.60
NEURON	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
REMYELINATION	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
GENE EXPRESSION	regulates	concept	0.50
MYELIN	protects_against	concept	0.50
DEMYELINATION	protects_against	concept	0.50
Spinal Cord	activates	cell_type	0.50
OLIGODENDROCYTES	activates	concept	0.50
disease	inhibits	disease	0.50
White Matter	inhibits	process	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
Spinal Cord	inhibits	cell_type	0.50
OLIGODENDROCYTES	regulates	concept	0.50
AXON	expressed_in	concept	0.50
T Cell	associated_with	cell_type	0.50
VESICLE TRAFFICKING	activates	concept	0.50
Proteins	associated_with	protein	0.50
MYELIN	causes	concept	0.50
OLIGODENDROCYTES	causes	concept	0.50
MYELIN	expressed_in	concept	0.50
Epilepsy	associated_with	disease	0.50
Oligodendrocyte	associated_with	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
Neural Stem Cell	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
SPHINGOLIPID	co_discussed	entity	0.50
SPINAL CORD	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
SEEDING	co_discussed	entity	0.50
UNFOLDED PROTEIN RESPONSE	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
PSP	co_discussed	entity	0.50
AXON	protects_against	entity	0.50
STAT3	co_discussed	entity	0.50
SREBF2	co_discussed	entity	0.50
AXON	activates	concept	0.50
NEURODEGENERATION	causes	entity	0.50

Incoming (500)

Source	Relation	Type	Str
Iron	involved_in	compound	0.95
APOE4	associated_with	gene	0.95
OCN	inhibits	protein	0.95
Cholesterol Dysregulation	inhibits	mechanism	0.90
APOE4	impairs	gene	0.90
Microglia Activation	regulates	process	0.85
GBA1	regulates	gene	0.80
HDAC7	regulates	protein	0.80
Microglia	regulates	cell_type	0.80
COMPLEMENT	causes	gene	0.60
AQP4	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
CD19	causes	gene	0.60
ASTROCYTE	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
C9ORF72	interacts_with	gene	0.60
INFLAMMATION	causes	gene	0.60
SOD1	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
VEGF	expressed_in	gene	0.60
SOD1	contributes_to	gene	0.60
MICROGLIA	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
AQUAPORIN-4	causes	gene	0.60
OVERVIEW	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
TNF	expressed_in	gene	0.60
GABRA1	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	gene	0.60
C4B	associated_with	gene	0.60
OVERVIEW	inhibits	gene	0.60
CYTOKINES	activates	gene	0.60
JUN	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
COMPLEMENT	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
SOD1	regulates	gene	0.60
EPILEPSY	causes	gene	0.60
INFLAMMATION	regulates	gene	0.60
OPTINEURIN	regulates	gene	0.60
APOE	regulates	gene	0.60
GABRG2	causes	gene	0.60
GENES	causes	gene	0.60
IL-6	expressed_in	gene	0.60
BANG	activates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Oligodendrocyte Remyelination Enhancement	0.644	neurodegeneration	Gene expression changes in aging mouse b
MOG-IgG induces spinal cord demyelination through Fcγ recept	0.560	neuroinflammation	What are the specific pathophysiological
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.536	neurodegeneration	Cell type vulnerability in Alzheimer's D
Oligodendrocyte Lineage Vulnerability: Early Myelination Dis	0.530	neurodegeneration	Cell type vulnerability debate in Alzhei

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progre [PMID:41342370]	Cheng Y, Huang G, Liu X, Wu C, Lian J et	Cancer Res	2026
ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017]	Huang F, Zhu Z, Xing Q, Li M	Biochimie	2026
Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophagea [PMID:41483805]	Zhou P, Zhang Y, Zhang H, Zhao P, Guo Y	Cell Rep Med	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
TREM2 and microglial immunity in Alzheimer's disease: mechanisms, genetics, and [PMID:41789102]	Wang T, Liu X, Wang X, Hua F, Yan L	Front Immunol	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233]	Li Y, Tang Q, Li L, Lin C, Guo M et al.	Front Bioeng Biotechnol	2025

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MYELINATION in their description or question text

No additional research found