concept

OPC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

2Hypotheses

2Analyses

5Outgoing

38Incoming

4Experiments

8Debates

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💡 Concept Info

Name	OPC
Related Pathways	tau propagation
Linked Hypotheses	2 hypotheses

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    OPC["OPC"]
    OPC -->|"expressed in"| White_Matter["White Matter"]
    OPC -->|"expressed in"| Cortex["Cortex"]
    OPC -->|"expressed in"| Hippocampus["Hippocampus"]
    RNA["RNA"] -->|"regulates"| OPC
    GPR37["GPR37"] -->|"regulates"| OPC
    MYELIN["MYELIN"] -->|"regulates"| OPC
    DEMENTIA["DEMENTIA"] -->|"interacts"| OPC
    SERPINE2["SERPINE2"] -->|"activates"| OPC
    TAUOPATHY["TAUOPATHY"] -->|"activates"| OPC
    ASTROCYTE["ASTROCYTE"] -->|"activates"| OPC

Outgoing (5)

Target	Relation	Type	Str
oligodendrocyte	associated_with	cell_type	0.75
White Matter	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
tau propagation	associated_with	mechanism	0.50

Incoming (38)

Source	Relation	Type	Str
RNA	regulates	gene	0.60
MYELIN	regulates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
COP1	causes	gene	0.60
MICROGLIA	inhibits	gene	0.60
GBM	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
STROKE	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
APOE	associated_with	gene	0.60
CD44	expressed_in	gene	0.60
GPR37	regulates	gene	0.60
LDLR	associated_with	gene	0.60
TAU	activates	gene	0.60
RNA	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
SERPINE2	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
MYELIN	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
KCND2	associated_with	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
FLOT1	causes	gene	0.60
EPILEPSY	associated_with	gene	0.60
MTOR	expressed_in	gene	0.60
SLC12A5	causes	gene	0.60
Cancer	associated_with	disease	0.55
Traumatic Brain Injury	expressed_in	disease	0.55
Ischemia	expressed_in	disease	0.55
Als	inhibits	disease	0.55
Als	activates	disease	0.55
Vascular Dementia	interacts_with	disease	0.55
Ischemia	interacts_with	disease	0.55
Neurodegeneration	activates	disease	0.55
Als	expressed_in	disease	0.55
Als	regulates	disease	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
OPC differentiation blockade contributes to white matter deg	0.599	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent M	0.508	Alzheimer disease	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (2)

Scientific analyses that reference this entity

Spatially Resolved Oligodendrocyte-Astrocyte Communication Networks Disrupted in

neurodegeneration | 2026-04-27 | 0 hypotheses

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.869

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice	validation	Alzheimer's disease	0.950	APP/PS1 transgenic mice (8 mon	proposed	N/A
PDGFRA and C-MYC protein validation in ovarian cancer tissues	exploratory	Ovarian cancer	0.850	Human ovarian cancer tissues	proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A
Early disease phase characterized by remyelination response from oligo	cell_biology	Alzheimer's disease	0.500	human	extracted	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149]	Li C, Teng T, Lin X, Sun X, Yi T et al.	Cancer Res	2026
A cellular epigenetic classification system for glioblastoma. [PMID:41499453]	Silverbush D, Jürgensen L, Freeburg NF,	Neuro Oncol	2026
Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491]	Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan	J Gastroenterol Hepatol	2026
P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526]	Yan L, Zheng J, Lu Z, Zhu A, Ye M et al.	Circulation	2026
Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834]	Ye D, Zhou H, Qu S, Wang Z, Zhang F et a	Cell Death Discov	2026
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogra [PMID:40816266]	Lu JY, Tu WB, Li R	Cell	2025
The neuropathobiology of multiple sclerosis. [PMID:38789516]	Woo MS, Engler JB, Friese MA	Nat Rev Neurosci	2024
Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180]	Simats A, Zhang S, Messerer D	Cell	2024
The neuropathobiology of multiple sclerosis. [PMID:38789516]	Woo MS, Engler JB, Friese MA	Nature reviews. Neuroscience	2024
Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180]	Simats A, Zhang S, Messerer D, Chong F,	Cell	2024
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680]	Unknown	Cell	2023
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678]	Depp C, Sun T, Sasmita AO	Nature	2023
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680]	Xiong, James, Boix, Park, Galani et al.	Cell	2023
Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328]	Zou P, Wu C, Liu TC, Duan R, Yang L	Translational neurodegeneratio	2023
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678]	Depp C, Sun T, Sasmita AO, Spieth L, Ber	Nature	2023
Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328]	Zou P, Wu C, Liu TC, Duan R, Yang L	Translational neurodegeneratio	2023
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558]	Unknown	Nature neuroscience	2019
Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662]	["Kuhn Sarah", "Gritti Laura", "Crooks D	Cells	2019
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558]	Unknown	Nature neuroscience	2019
Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662]	["Kuhn Sarah", "Gritti Laura", "Crooks D	Cells	2019

Debates (8)

Multi-agent debates referencing this entity

What spatially resolved cell-cell communication networks between oligodendrocyte

active · Rounds: 6 · Score: 0.83 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

closed · Rounds: 4 · Score: 0.12 · 2026-04-27

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

closed · Rounds: 4 · Score: 0.42 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

closed · Rounds: 4 · Score: 0.47 · 2026-04-27

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

closed · Rounds: 4 · Score: 0.52 · 2026-04-27

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

closed · Rounds: 4 · Score: 0.72 · 2026-04-27

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

Related Research

Hypotheses and analyses mentioning OPC in their description or question text

No additional research found

OPC