gene

SLC22A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC22A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

12Outgoing

31Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	SLC22A1
Full Name	Solute Carrier Family 22 Member 1 (OCT1)
Chromosome	11q13.4
Function	encodes a polytopic membrane protein with 12 predicted transmembrane domains, characteristic of the major facilitator superfamily (MFS).
Molecular Weight	61 kDa
Amino Acids	554 aa
Exons	12
UniProt ID	O15245
NCBI Gene ID	6579
Ensembl ID	ENSG00000175084
OMIM	607607
GeneCards	SLC22A1
Human Protein Atlas	SLC22A1
Associated Diseases	neurodegeneration
Interactions	ABCB1, CHAT, CHRNA7, CYP2D6, CYP3A4, DEMENTIA
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC22A1 — AlphaFold O15245 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

slc22a1

gene · 2913 words

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Pathway Diagram

graph TD
    SLC22A1["SLC22A1"]
    Vascular_Dementia["Vascular Dementia"]
    SLC22A1 -->|"transports"| Vascular_Dementia
    Alzheimer["Alzheimer"]
    SLC22A1 -->|"transports"| Alzheimer
    Dementia["Dementia"]
    SLC22A1 -->|"transports"| Dementia
    ALS["ALS"]
    SLC22A1 -->|"transports"| ALS
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    SLC22A1 -->|"transports"| Frontotemporal_Dementia
    CYP3A4["CYP3A4"]
    SLC22A1 -->|"transports"| CYP3A4
    PPAR["PPAR"]
    PPAR -->|"transports"| SLC22A1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"transports"| SLC22A1
    GENES["GENES"]
    GENES -->|"transports"| SLC22A1
    APOE["APOE"]
    APOE -->|"transports"| SLC22A1
    ABCB1["ABCB1"]
    ABCB1 -->|"transports"| SLC22A1
    CHAT["CHAT"]
    CHAT -->|"transports"| SLC22A1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"transports"| SLC22A1
    ACE["ACE"]
    ACE -->|"transports"| SLC22A1
    POR["POR"]
    POR -->|"transports"| SLC22A1
    BCHE["BCHE"]
    BCHE -->|"transports"| SLC22A1
    CYP3A5["CYP3A5"]
    CYP3A5 -->|"transports"| SLC22A1
    NR1I2["NR1I2"]
    NR1I2 -->|"transports"| SLC22A1
    AND["AND"]
    AND -->|"transports"| SLC22A1
    CHRNA7["CHRNA7"]
    CHRNA7 -->|"transports"| SLC22A1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"transports"| SLC22A1
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"transports"| SLC22A1
    Neuron["Neuron"]
    SLC22A1 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    SLC22A1 -->|"implicated in"| neurodegeneration

Outgoing (12)

Target	Relation	Type	Str
Alzheimer	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Dementia	transports	disease	0.65
Vascular Dementia	transports	disease	0.65
CYP3A4	transports	gene	0.60
Neuron	expressed_in	cell_type	0.55
CYP3A4	interacts_with	gene	0.50
PPAR	interacts_with	protein	0.50
CHRNA7	interacts_with	gene	0.50
DEMENTIA	interacts_with	gene	0.50
Proteins	interacts_with	protein	0.50

Incoming (31)

Source	Relation	Type	Str
CYP3A5	regulates	gene	0.60
NR1I2	regulates	gene	0.60
POR	regulates	gene	0.60
DEMENTIA	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
POR	transports	gene	0.60
CYP3A5	transports	gene	0.60
NR1I2	transports	gene	0.60
AND	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
PPAR	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CHAT	transports	gene	0.60
ACE	transports	gene	0.60
BCHE	transports	gene	0.60
CHRNA7	transports	gene	0.60
CYP2D6	transports	gene	0.60
CYP2C19	regulates	gene	0.60
ABCB1	regulates	gene	0.60
ACE	regulates	gene	0.60
CHAT	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
CYP2D6	regulates	gene	0.60
CYP3A4	regulates	gene	0.60
PPAR	regulates	gene	0.60
acetylcholine	interacts_with	disease	0.50
ABCB1	interacts_with	gene	0.50
CYP2D6	interacts_with	gene	0.50
CHAT	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC22A1 in their description or question text

No additional research found