concept

HIPPOCAMPUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPOCAMPUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2000Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

HIPPOCAMPUS is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, causes. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 84 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPOCAMPUS
Key Genes/Proteins	ABCA7, ABI3, ACHE, ACSL4, ADAM10, AIF1
Related Diseases	ACETYLCHOLINE, AGING, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ripple-Associated Interneurons (Hippocampus)

cell · 767 words

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Pathway Diagram

graph TD
    HIPPOCAMPUS["HIPPOCAMPUS"]
    HIPPOCAMPUS -->|"activates"| Memory["Memory"]
    HIPPOCAMPUS -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    BDNF["BDNF"] -->|"expressed in"| HIPPOCAMPUS
    BMSC_exos["BMSC-exos"] -->|"expressed in"| HIPPOCAMPUS
    SNCA["SNCA"] -->|"expressed in"| HIPPOCAMPUS
    mitophagy["mitophagy"] -->|"expressed in"| HIPPOCAMPUS
    blood_brain_barrier["blood-brain barrier"] -->|"regulates"| HIPPOCAMPUS
    neurogenesis["neurogenesis"] -->|"expressed in"| HIPPOCAMPUS
    SMAD7["SMAD7"] -->|"expressed in"| HIPPOCAMPUS
    autophagy["autophagy"] -->|"expressed in"| HIPPOCAMPUS
    GFAP["GFAP"] -->|"expressed in"| HIPPOCAMPUS
    senescent_microglia["senescent microglia"] -->|"expressed in"| HIPPOCAMPUS

Outgoing (635)

Target	Relation	Type	Str
NEUROGENESIS	regulates	process	0.95
MICROGLIA	regulates	cell_type	0.95
memory	involved_in	phenotype	0.95
NEURON	protects_against	cell_type	0.95
NEUROGENESIS	associated_with	process	0.95
NEURON	regulates	cell_type	0.95
NEURON	activates	cell_type	0.95
stress response	involved_in	process	0.90
Post-Stroke Depression	correlates_with	disease	0.85
cognitive performance	mediates	phenotype	0.85
NEURON	interacts_with	cell_type	0.80
NEUROINFLAMMATION	inhibits	process	0.80
cognitive decline	involved_in	phenotype	0.80
TAU	activates	protein	0.80
NEURON	therapeutic_target	cell_type	0.80
MICROGLIA	inhibits	cell_type	0.80
NEURODEGENERATION	causes	process	0.80
Alzheimer disease	vulnerability_locus_for	disease	0.75
Memory	activates	entity	0.70
AMYLOID	protects_against	protein	0.70
NEUROGENESIS	treats	phenotype	0.70
PARKINSON	stabilizes	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
AKT	stabilizes	gene	0.70
PARKINSON	treats	disease	0.70
NEURON	biomarker_for	cell_type	0.65
MAPT	activates	gene	0.65
PI3K	activates	gene	0.65
NEURODEGENERATION	activates	disease	0.65
PSEN2	activates	gene	0.65
NEUROINFLAMMATION	activates	process	0.65
ASTROCYTE	causes	cell_type	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65
GLUTAMATE	causes	phenotype	0.65
OXIDATIVE STRESS	inhibits	process	0.65
STRIATUM	expressed_in	brain_region	0.65
CYTOKINES	regulates	phenotype	0.65
DENTATE GYRUS	inhibits	brain_region	0.65
WNT	phosphorylates	gene	0.65
MTOR	activates	gene	0.65
TAU	targets	gene	0.65
LOCUS COERULEUS	exacerbates	brain_region	0.65
INTERNEURONS	expressed_in	cell_type	0.65
PSD95	increases	gene	0.65
MICROGLIA	activates	cell_type	0.65
PREFRONTAL	contributes_to	brain_region	0.65
NRF2	inhibits	gene	0.65
NLRP3	phosphorylates	gene	0.65
PSEN2	regulates	gene	0.65
IL-6	contributes_to	gene	0.65

Incoming (1365)

Source	Relation	Type	Str
TAU	associated_with	protein	1.00
MICROGLIA	activates	cell_type	1.00
BDNF	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
NF-KB	associated_with	protein	1.00
MICROGLIA	associated_with	cell_type	1.00
APP	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
ASTROCYTES	associated_with	cell_type	1.00
CORTEX	regulates	brain_region	0.95
APP	expressed_in	gene	0.95
CORTEX	inhibits	brain_region	0.95
ALZHEIMER'S DISEASE	interacts_with	disease	0.95
DEPRESSION	activates	disease	0.95
CORTEX	activates	brain_region	0.95
SLC17A7	enriched_in	gene	0.95
HCN2	expressed_in	gene	0.90
epilepsy	affects	disease	0.90
RNA	expressed_in	gene	0.90
synaptic plasticity	active_in	pathway	0.90
depression	affects	disease	0.90
BDNF	inhibits	gene	0.90
BDNF-TrkB signaling	active_in	pathway	0.90
HCN1	expressed_in	entity	0.90
neurodegeneration	affects	disease	0.90
TNF	expressed_in	gene	0.90
aging	affects	disease	0.90
microglia	expressed_in	cell_type	0.90
SPP1	expressed_in	entity	0.90
BDNF	expressed_in	gene	0.90
Alzheimer's disease	affects	disease	0.90
APP	expressed_in	gene	0.90
glutamate signaling	active_in	pathway	0.90
neuroinflammation	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
NMDA receptor	expressed_in	receptor	0.90
1-bromopropane	causes	compound	0.90
PVB	expressed_in	gene	0.90
IL-6	associated_with	gene	0.90
Neurodegeneration-Related Gene Expression	expressed_in	process	0.90
BCL2	expressed_in	protein	0.88
TREM2	expressed_in	gene	0.88
C4B	upregulated_in	gene	0.85
MICROGLIA	expressed_in	entity	0.85
hypoxic-ischemic brain injury	associated_with	disease	0.85
Cadmium	causes	compound	0.85
TDP43	expressed_in	entity	0.85
C1Q	expressed_in	entity	0.85
MCH	expressed_in	protein	0.85
Neuronal Cholesterol Accumulation	expressed_in	phenotype	0.85