Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYP3A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CYP3A5 |
| Key Genes/Proteins | ABCB1, ABCG2, ACE, ADRA2A, ADRB2, ALZHEIMER |
| Related Diseases | Als, ALS, Alzheimer, Alzheimer's disease, Anxiety |
graph TD
CYP3A5["CYP3A5"]
CYP3A5 -->|"involved_in"| Metabolic_Processes["Metabolic Processes"]
CYP3A5 -->|"interacts"| Dementia["Dementia"]
CYP3A5 -->|"target for"| Alzheimer["Alzheimer"]
CYP3A5 -->|"target for"| Als["Als"]
CYP3A5 -->|"transports"| Vascular_Dementia["Vascular Dementia"]
PER["PER"] -->|"interacts"| CYP3A5
GENES["GENES"] -->|"interacts"| CYP3A5
POR["POR"] -->|"target for"| CYP3A5
PPAR["PPAR"] -->|"transports"| CYP3A5
DEMENTIA["DEMENTIA"] -->|"transports"| CYP3A5
APOE["APOE"] -->|"transports"| CYP3A5
ABCB1["ABCB1"] -->|"transports"| CYP3A5| Target | Relation | Type | Str |
|---|---|---|---|
| Metabolic Processes | involved_in | process | 0.80 |
| Als | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Anxiety | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Vascular Dementia | transports | disease | 0.65 |
| Alzheimer | transports | disease | 0.65 |
| Dementia | transports | disease | 0.65 |
| ALS | transports | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | transports | disease | 0.65 |
| Frontotemporal Dementia | therapeutic_target | disease | 0.65 |
| Vascular Dementia | therapeutic_target | disease | 0.65 |
| NBEA | associated_with | gene | 0.60 |
| POR | therapeutic_target | gene | 0.60 |
| Ras | therapeutic_target | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Rb | associated_with | protein | 0.60 |
| GBA3 | interacts_with | gene | 0.60 |
| SLC22A2 | interacts_with | gene | 0.60 |
| UGT3A1 | interacts_with | gene | 0.60 |
| Insulin | associated_with | protein | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| PER | therapeutic_target | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| MAOB | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| CYP2C18 | associated_with | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| CHAT | therapeutic_target | gene | 0.60 |
| CYP3A4 | therapeutic_target | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| CYP2D6 | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| ACE | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC6A3 | associated_with | gene | 0.60 |
| PER | interacts_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| MAOB | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| INSULIN RESISTANCE | associated_with | gene | 0.60 |
| CYP2C18 | associated_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| UGT3A1 | associated_with | gene | 0.60 |
| POR | therapeutic_target | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| CHRNA7 | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| NR1I2 | therapeutic_target | gene | 0.60 |
| PPAR | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| CHAT | therapeutic_target | gene | 0.60 |
| CYP2D6 | therapeutic_target | gene | 0.60 |
| COMT | interacts_with | gene | 0.60 |
| CYP2C18 | interacts_with | gene | 0.60 |
| PPAR | transports | gene | 0.60 |
| DEMENTIA | transports | gene | 0.60 |
| GENES | transports | gene | 0.60 |
| APOE | transports | gene | 0.60 |
| ABCB1 | transports | gene | 0.60 |
| CHAT | transports | gene | 0.60 |
| ALZHEIMER | transports | gene | 0.60 |
| ACE | transports | gene | 0.60 |
| POR | transports | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CYP3A5 in their description or question text
No additional research found