gene

RAB32

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

33Outgoing

23Incoming

0Experiments

0Debates

Summary

RAB32 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, contributes to. Associated with Als, Glioblastoma, Ms. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB32
Full Name	RAB32, Member RAS Oncogene Family
Chromosome	6q16.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	25 kDa
Amino Acids	225 aa
UniProt ID	[Q9NX93](https://www.uniprot.org/uniprot/Q9NX93)
Ensembl ID	ENSG00000116574
OMIM	613735
GeneCards	RAB32
Human Protein Atlas	RAB32
GTP-binding domain	The core domain that binds GTP/GDP and mediates switching between active and inactive states
Switch I region	Undergoes conformational changes upon GTP binding, mediating effector interactions
Switch II region	Critical for GTP hydrolysis and effector binding
Hypervariable C-terminal region	Contains cysteine residues for geranylgeranylation and membrane anchoring
Associated Diseases	Als, Ms, Parkinson, Parkinson's disease, Tumor
Interactions	LRRK2
KG Connections	56 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB32 Gene

gene · 1731 words

→

RAB32 Protein

protein · 623 words

→

Pathway Diagram

graph TD
    RAB32["RAB32"]
    Ms{"Ms"}
    RAB32 -->|"contributes to"| Ms
    Glioblastoma{"Glioblastoma"}
    RAB32 -->|"regulates"| Glioblastoma
    Tumor{"Tumor"}
    RAB32 -->|"associated with"| Tumor
    Als{"Als"}
    RAB32 -->|"associated with"| Als
    RAB32 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    RAB32 -->|"regulates"| Parkinson
    RAB32 -->|"regulates"| Als
    RAB32 -->|"associated with"| Parkinson
    DRP1["DRP1"]
    RAB32 -->|"regulates"| DRP1
    GBM["GBM"]
    RAB32 -->|"associated with"| GBM
    MMP9["MMP9"]
    RAB32 -->|"associated with"| MMP9
    MMP2["MMP2"]
    RAB32 -->|"associated with"| MMP2
    ERK["ERK"]
    ERK -->|"regulates"| RAB32
    RAS["RAS"]
    RAS -->|"contributes to"| RAB32
    GBM -->|"associated with"| RAB32
    DRP1 -->|"regulates"| RAB32
    MMP9 -->|"associated with"| RAB32
    MMP2 -->|"associated with"| RAB32
    style RAB32 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
Als	associated_with	disease	0.75
Parkinson	associated_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Ms	associated_with	disease	0.65
OPTN	regulates	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
DRP1	associated_with	gene	0.60
Invasion	contributes_to	pathway	0.60
Parkinson's disease	causes	disease	0.60
App	regulates	protein	0.60
VIMENTIN	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
SNCA	causes	gene	0.60
VPS35	causes	gene	0.60
DRP1	regulates	gene	0.60
SPG7	associated_with	gene	0.60
VCP	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
SNCA	associated_with	gene	0.60
GBM	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
LRRK2	activates	gene	0.60
ERK	regulates	gene	0.60
Parkinson's disease	associated_with	disease	0.60
Parkinson's disease	regulates	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
Parkinson's disease	activates	disease	0.60

Incoming (23)

Source	Relation	Type	Str
PARKINSON	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
GBM	associated_with	gene	0.60
DRP1	regulates	gene	0.60
MMP9	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
LRRK2	activates	gene	0.60
CHCHD2	causes	gene	0.60
GBA1	causes	gene	0.60
LRRK2	causes	gene	0.60
PARK7	causes	gene	0.60
PINK1	causes	gene	0.60
PRKN	causes	gene	0.60
ATXN2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
LRRK2	interacts_with	gene	0.60
LRRK2	associated_with	gene	0.60
ERK	regulates	gene	0.60
RAS	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB32 in their description or question text

No additional research found