concept

VASCULAR DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VASCULAR DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

1Hypotheses

0Analyses

47Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	VASCULAR DEMENTIA
Key Genes/Proteins	APOE, APP, CREB, MMP9
Related Diseases	GLUTAMATE, GLYCOLYSIS, NEUROINFLAMMATION
Related Pathways	NLRP3 INFLAMMASOME

Pathway Diagram

graph TD
    VASCULAR_DEMENTIA["VASCULAR DEMENTIA"]
    style VASCULAR_DEMENTIA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    VASCULAR_DEMENTIA -->|"causes"| Cerebrovascular["Cerebrovascular"]
    VASCULAR_DEMENTIA -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Myelination["Myelination"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Apoptosis["Apoptosis"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Inflammasome["Inflammasome"]
    VASCULAR_DEMENTIA -->|"activates"| Dendritic_Spine["Dendritic Spine"]
    VASCULAR_DEMENTIA -->|"activates"| Camp_Signaling["Camp Signaling"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Amyloid["Amyloid"]
    Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"causes"| VASCULAR_DEMENTIA
    FERROPTOSIS["FERROPTOSIS"] -->|"contributes to"| VASCULAR_DEMENTIA
    CHRONIC_CEREBRAL_HYPOPERFUSION["CHRONIC CEREBRAL HYPOPERFUSION"] -->|"causes"| VASCULAR_DEMENTIA
    Tong_Qiao_Huo_Xue_Decoction{"Tong-Qiao-Huo-Xue Decoction"} -->|"treats"| VASCULAR_DEMENTIA
    Cerebrovascular_Disease["Cerebrovascular Disease"] -->|"risk_factor_for"| VASCULAR_DEMENTIA
    NLRP3([NLRP3]) -->|"contributes to"| VASCULAR_DEMENTIA
    Ams_17["Ams-17"] -->|"treats"| VASCULAR_DEMENTIA
    AMS_17["AMS-17"] -->|"treats"| VASCULAR_DEMENTIA
    A3AR["A3AR"] -->|"treats"| VASCULAR_DEMENTIA

Outgoing (47)

Target	Relation	Type	Str
Tau Protein Hyperphosphorylation	associated_with	mechanism	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.85
NLRP3	associated_with	protein	0.85
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
Vitamin D	associated_with	chemical	0.70
endothelial cells	affects	cell_type	0.60
lipid metabolism	involves	pathway	0.60
neural stem cells	affects	cell_type	0.60
ferroptosis	involves	pathway	0.60
white matter	affects	brain_region	0.60
blood-brain barrier	affects	brain_region	0.60
Cerebrovascular	causes	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Opc	interacts_with	cell_type	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Endothelial	therapeutic_target	cell_type	0.55
Inflammasome	therapeutic_target	pathway	0.55
Oligodendrocyte	interacts_with	cell_type	0.55
Neuron	activates	cell_type	0.55
Neuron	therapeutic_target	cell_type	0.55
Endothelial	associated_with	cell_type	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Ferroptosis	associated_with	pathway	0.55
Calcium Signaling	expressed_in	pathway	0.55
Blood-Brain Barrier	causes	pathway	0.55
Cerebrovascular	associated_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Amyloid	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Sod1	interacts_with	pathway	0.55
Amyloid	associated_with	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Myelination	inhibits	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Inflammasome	inhibits	pathway	0.55
Blood-Brain Barrier	inhibits	pathway	0.55
Apoptosis	activates	pathway	0.55
Dendritic Spine	activates	pathway	0.55
Camp Signaling	activates	pathway	0.55
Amyloid	inhibits	pathway	0.55
APOE	associated_with	gene	0.50
Cortex	associated_with	brain_region	0.50
Hippocampus	associated_with	brain_region	0.50
APP	associated_with	gene	0.50
White Matter	associated_with	brain_region	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.45
CREB	associated_with	gene	0.45

Incoming (166)

Source	Relation	Type	Str
FERROPTOSIS	contributes_to	entity	0.95
CHRONIC CEREBRAL HYPOPERFUSION	causes	entity	0.95
Chronic Cerebral Hypoperfusion	causes	process	0.95
Tong-Qiao-Huo-Xue Decoction	treats	drug	0.95
Cerebrovascular Disease	risk_factor_for	disease	0.90
Chronic Cerebral Hypoperfusion	contributes_to	disease	0.90
cardiovascular disease	causes	disease	0.90
Nerve cell damage	contributes_to	phenotype	0.90
NLRP3	contributes_to	protein	0.90
Ams-17	treats	compound	0.85
Oligodendrocytes	involved_in	cell_type	0.85
PAL	treats	compound	0.85
TNF-α	biomarker_for	protein	0.80
A3AR	treats	receptor	0.80
Ferroptosis	accelerates	process	0.80
BDNF	biomarker_for	protein	0.80
MMP9	contributes_to	protein	0.75
FERROPTOSIS	effect_on	process	0.70
CREB	activates	gene	0.65
EXOSOMES	inhibits	gene	0.65
ALZHEIMER	inhibits	gene	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.65
AMYLOID	inhibits	gene	0.65
TAU	inhibits	gene	0.65
DEMENTIA	transports	gene	0.65
CYP3A5	therapeutic_target	gene	0.65
ABCB1	therapeutic_target	gene	0.65
CHAT	therapeutic_target	gene	0.65
NR1I2	therapeutic_target	gene	0.65
CYP3A4	therapeutic_target	gene	0.65
PPAR	therapeutic_target	gene	0.65
ACE	therapeutic_target	gene	0.65
CHRNA7	therapeutic_target	gene	0.65
CYP2D6	therapeutic_target	gene	0.65
AND	causes	gene	0.65
DEMENTIA	activates	gene	0.65
ROS	activates	gene	0.65
AND	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
SYNAPSE	activates	gene	0.65
ABCB1	transports	gene	0.65
CHAT	transports	gene	0.65
ACE	transports	gene	0.65
POR	associated_with	gene	0.65
BCHE	transports	gene	0.65
CYP3A5	transports	gene	0.65
NR1I2	transports	gene	0.65
CHRNA7	transports	gene	0.65
CYP2D6	transports	gene	0.65
SLC22A1	transports	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VASCULAR DEMENTIA in their description or question text

No additional research found