gene 2,502 words KG: VAMP8
Contents

VAMP8 — Vesicle Associated Membrane Protein 8

🧬 Gene Info
Gene SymbolVAMP8
Full NameVesicle Associated Membrane Protein 8
Chromosome2p12
Functionis a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family essential for intracellular vesicle fusion events[@borre2012].
Primary ExpressionBrain, Pancreas, Kidney, Heart, Liver, Lung
Amino Acids116 aa
Exons5
PathwaysAutophagy, Cell Cycle, Lysosomal Degradation, Mitophagy
UniProt IDQ15886
NCBI Gene ID9529
Ensembl IDENSG00000118640
OMIM603177
GeneCardsVAMP8
Human Protein AtlasVAMP8
N-terminal region (aa 1-30)Variable domain involved in protein-protein interactions
Associated DiseasesAls, Glioblastoma, Melanoma, Ms, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsACAT1, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections456 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (20)

Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (13)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ACTB Gene
gene · KG edge: activates
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: activates

Knowledge Graph (12 edges)

VAMP8 associated_with LAMP2
VAMP8 associated_with GBM
VAMP8 associated_with LC3
VAMP8 associated_with EPG5
VAMP8 associated_with STX17
VAMP8 associated_with SQSTM1
VAMP8 associated_with SNAP29
VAMP8 associated_with SDC1
VAMP8 associated_with TGM2
OPTN associated_with VAMP8

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