gene

apaf1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about apaf1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APAF1
Aliases	Apoptotic Protease-Activating Factor 1
Protein Type	Gene
Function	is a critical regulator of the intrinsic (mitochondrial) apoptosis pathway.
Molecular Weight	130 kDa
Pathways	apoptosis
GeneCards	APAF1
Human Protein Atlas	APAF1
Associated Diseases	Neurodegeneration, Alzheimer's disease pathogenesis
Interactions	AMPK, APOPTOTIC PROTEASE ACTIVATING FACTOR 1
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APAF1 Gene

gene · 1145 words

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Pathway Diagram

graph TD
    APAF1["APAF1"]
    APAF1 -->|"participates in"| apoptosis["apoptosis"]
    APAF1 -->|"activates"| caspase_9["caspase-9"]
    APAF1 -->|"activates"| caspase_3["caspase-3"]
    APAF1 -->|"participates in"| axon_degeneration["axon_degeneration"]
    APAF1 -->|"implicated in"| neurodegenerative_diseases["neurodegenerative_diseases"]
    APAF1 -.biomarker for.-> Melanoma["Melanoma"]
    APAF1 -->|"activates"| Inflammation["Inflammation"]
    APAF1 -->|"activates"| Als["Als"]
    TCTP["TCTP"] -->|"binds"| APAF1
    TP53["TP53"] -->|"participates in"| APAF1
    CYTC["CYTC"] -->|"participates in"| APAF1
    STING["STING"] -->|"regulates"| APAF1
    GENES["GENES"] -->|"activates"| APAF1
    NRF2["NRF2"] -->|"regulates"| APAF1
    CYLD["CYLD"] -->|"activates"| APAF1
    AMPK["AMPK"] -->|"activates"| APAF1

Outgoing (54)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APAF1	data_in	dataset_row	0.00
caspase-9	activates	protein	0.80
caspase-3	activates	protein	0.80
Melanoma Progression	associated_with	biological_process	0.80
axon_degeneration	participates_in	biological_process	0.80
neurodegenerative_diseases	implicated_in	disease	0.70
Melanoma	biomarker_for	disease	0.70
Necroptosis	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Er Stress	activates	pathway	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
LC3B	regulates	gene	0.60
MICROTUBULES	associated_with	gene	0.60
AXON	regulates	gene	0.60
SYNAPSE	expressed_in	gene	0.60
Apoptosis	activates	pathway	0.60
Neuron	regulates	cell_type	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IL-1B	inhibits	gene	0.60
TBK1	regulates	gene	0.60
CASPASE3	regulates	gene	0.60
BECLIN1	regulates	gene	0.60
ATG5	regulates	gene	0.60
BAX	regulates	gene	0.60
BNIP3	regulates	gene	0.60
CYTC	regulates	gene	0.60
P62	regulates	gene	0.60
BCL2	regulates	gene	0.60
Rb	activates	protein	0.60
AMPK	activates	gene	0.60
TXNIP	activates	gene	0.60
Immune Response	inhibits	pathway	0.60
Raf	activates	protein	0.60
Il-1	inhibits	protein	0.60
Neuron	expressed_in	cell_type	0.55
Hippocampus	expressed_in	brain_region	0.55
MICROTUBULES	inhibits	concept	0.50
AXON	inhibits	concept	0.50
AMPK	activates	protein	0.50
AMPK	inhibits	protein	0.50
AXON	regulates	concept	0.50
NEURONS	regulates	concept	0.50
apoptosis	activates	process	0.50
NEURONS	activates	concept	0.50
APOPTOTIC PROTEASE ACTIVATING FACTOR 1	activates	protein	0.50
AXON	activates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APAF1	data_in	dataset_row	0.00
TCTP	binds	protein	0.80
TP53	participates_in	gene	0.70
CYTC	participates_in	protein	0.70
CYLD	activates	gene	0.60
STING	regulates	gene	0.60
SYNAPSE	expressed_in	gene	0.60
NRF2	regulates	gene	0.60
AXON	regulates	gene	0.60
CALR	inhibits	gene	0.60
RIPK1	inhibits	gene	0.60
TNFSF10	activates	gene	0.60
PAH	activates	gene	0.60
CANX	inhibits	gene	0.60
PYCARD	activates	gene	0.60
GENES	activates	gene	0.60
AMPK	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROTUBULES	associated_with	gene	0.60
AMPK	implicated_in	gene	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning apaf1 in their description or question text

No additional research found