gene

NPAS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

9Outgoing

0Incoming

0Experiments

0Debates

Summary

NPAS3 encodes a brain-specific transcription factor essential for neuronal development, synaptic plasticity, and cognitive function. Implicated in Alzheimer's disease, schizophrenia, and intellectual disability

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🧬 Gene Info

Gene Symbol	NPAS3
Full Name	Neuronal PAS Domain Protein 3
Chromosome	12q23.3
Protein Type	Transcription Factor
Function	encodes a brain-specific transcription factor belonging to the bHLH-PAS (basic Helix-Loop-Helix-Per-Arnt-Sim) family of transcriptional regulators.
Primary Expression	Brain-specific (neurons)
Molecular Weight	65 kDa
Amino Acids	593 aa
Exons	27
UniProt ID	[Q8TDW5](https://www.uniprot.org/uniprot/Q8TDW5)
Ensembl ID	ENSG00000173137
GeneCards	NPAS3
Human Protein Atlas	NPAS3
Associated Diseases	Alzheimer's Disease, Intellectual Disability, Parkinson's Disease, Pulmonary Hypoplasia, Schizophrenia
KG Connections	9 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NPAS3 Gene

gene · 4037 words

→

NPAS3 Protein

protein · 644 words

→

Pathway Diagram

flowchart TD
    N0["NPAS3"]
    N1["Intellectual Disability"]
    N0 -->|"associated with"| N1
    N2["Schizophrenia"]
    N0 -->|"associated with"| N2
    N3["ARNT"]
    N0 -->|"binds"| N3
    N4["VGF"]
    N0 -->|"regulates"| N4
    N5["TXNIP"]
    N0 -->|"regulates"| N5
    N6["Alzheimer's Disease"]
    N0 -->|"associated with"| N6
    N7["Parkinson's Disease"]
    N0 -->|"associated with"| N7
    N8["Pulmonary Hypoplasia"]
    N0 -->|"causes"| N8
    N9["Congenital Diaphragmatic Hernia"]
    N0 -->|"downregulates"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N4 gene
    class N5 gene
    class N6 disease
    class N7 disease
    class N8 disease
    class N9 disease

Outgoing (9)

Target	Relation	Type	Str
Intellectual Disability	associated_with	disease	0.80
ARNT	binds	entity	0.80
VGF	regulates	gene	0.80
TXNIP	regulates	gene	0.80
Pulmonary Hypoplasia	causes	disease	0.80
Congenital Diaphragmatic Hernia	downregulates	disease	0.80
Schizophrenia	associated_with	disease	0.80
Alzheimer's Disease	associated_with	disease	0.80
Parkinson's Disease	associated_with	disease	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPAS3 in their description or question text

No additional research found