Contents

STING1 Gene

🧬 Gene Info

Gene Symbol	STING1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	DNA sensing: cGAS (cyclic GMP-AMP synthase) binds cytosolic dsDNA from any source — mitochondrial, nuclear, microbial, or retrotransposon-derived
Mechanism of Action	Small molecule agonists or antagonists of cGAS-STING pathway activation
Druggability	Low (0.40)
Clinical Stage	Phase II
Pathways	Akt, Autophagy, Immune Response, Wnt, innate_immune_response
UniProt ID	A0A494C1N5
Ensembl ID	ENSG00000184584
GeneCards	STING1
Human Protein Atlas	STING1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	cGAMP, palmitic acid, Palmitic Acid, PA treatment, rapamycin, VS-X4
Interactions	ABCD3, ACOX1, Actin, Adiponectin, ADIPOQ, AKT1
SciDEX Target	View Target Profile (3 clinical trials)
SciDEX Hypotheses	Mitochondrial NAD+ Salvage Enhancement
KG Connections	1279 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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Knowledge Graph

CGAS interacts_with STING1

STING1 interacts_with CGAS

STING1 interacts_with DNASE2

DNASE2 interacts_with STING1

MMP9 co_discussed STING1

SLC7A11 co_discussed STING1

AQP4 co_discussed STING1

CD38 co_discussed STING1

C1Q co_discussed STING1

NAMPT co_discussed STING1