Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOIMMUNITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AUTOIMMUNITY |
| Key Genes/Proteins | STING1 |
graph TD
AUTOIMMUNITY["AUTOIMMUNITY"]
STING["STING"] -->|"involved_in"| AUTOIMMUNITY
CSNK1A1["CSNK1A1"] -.protects against.-> AUTOIMMUNITY
STAT1_gain_of_function_mutatio["STAT1 gain-of-function mutations"] -->|"causes"| AUTOIMMUNITY
CGAS_STING_pathway["CGAS-STING pathway"] -->|"causes"| AUTOIMMUNITY
Aberrant_Protein_Assemblies["Aberrant Protein Assemblies"] -->|"causes"| AUTOIMMUNITY
Testosterone["Testosterone"] -->|"modulates"| AUTOIMMUNITY
Epstein_Barr_Virus["Epstein-Barr Virus"] -->|"mediates"| AUTOIMMUNITY
cGAS_STING_pathway["cGAS-STING pathway"] -->|"causes"| AUTOIMMUNITY| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| STING | involved_in | protein | 0.90 |
| STING1 | associated_with | protein | 0.90 |
| CSNK1A1 | protects_against | protein | 0.85 |
| Co-inhibitory Gene Module | associated_with | pathway | 0.85 |
| STAT1 gain-of-function mutations | causes | phenotype | 0.80 |
| CGAS-STING pathway | causes | pathway | 0.80 |
| Aberrant Protein Assemblies | causes | phenotype | 0.80 |
| GLYCAN SYNTHESIS | associated_with | biological_process | 0.80 |
| GLYCAN PROCESSING | associated_with | biological_process | 0.80 |
| Mitophagy | inhibits | process | 0.80 |
| IL17C | associated_with | gene | 0.80 |
| Treg | associated_with | cell_type | 0.80 |
| CTLA4 | risk_factor_for | gene | 0.80 |
| Trim21-Based Multimer-Selective Degraders | treats | mechanism | 0.75 |
| Trim21-Based Degraders | treats | mechanism | 0.75 |
| Testosterone | modulates | entity | 0.75 |
| Epstein-Barr Virus | mediates | process | 0.75 |
| Type I Interferon | exacerbates | biological_process | 0.70 |
| cGAS-STING pathway | causes | pathway | 0.70 |
| CAR T therapy | treats | drug | 0.70 |
| STING1 | causes | gene | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SPP1+ DAM as Source of Autoimmunity in Neurodegeneration | 0.660 | Alzheimer's disease | - |
| Combine Anti-AQP4 Autoimmunity Control with Astrocyte-Endfoo | 0.630 | neurodegeneration | How can AQP4 be effectively targeted the |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AUTOIMMUNITY in their description or question text
No additional research found