protein

CGAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2014Connections

9Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

2Debates

Summary

CGAS is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1017 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CGAS
Chromosome	6q15
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of cyclic dinucleotide synthesis
Mechanism of Action	Small molecule inhibitor of cyclic dinucleotide synthesis
Druggability	Medium (0.47)
Clinical Stage	Phase III
Molecular Weight	57 kDa
Amino Acids	522 aa
Exons	8
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Calcium Signaling
UniProt ID	Q8N884
NCBI Gene ID	115004
Ensembl ID	ENSG00000154122
GeneCards	CGAS
Human Protein Atlas	CGAS
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	Aberrant DNA, cGAS Inhibitors, Ginkgetin, Mitochondrial Dna, Mitochondrial DNA, mtDNA
Interactions	ACHE, Actin, AD, AGING, AHR, AKT
SciDEX Target	View Target Profile (4 clinical trials)
KG Connections	1980 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — CGAS Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

4LEV — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q8N884 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

hypothesis · 3017 words

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CGAS Gene

gene · 1814 words

→

Pathway Diagram

graph TD
    CGAS["CGAS"] -->|"activates"| STING["STING"]
    CGAS["CGAS"] -->|"activates"| NFKB["NFKB"]
    CGAS["CGAS"] -->|"activates"| IFN["IFN"]
    CGAS["CGAS"] -->|"mediates"| NEURODEGENERATION["NEURODEGENERATION"]
    CGAS["CGAS"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CGAS["CGAS"] -->|"interacts"| STING1["STING1"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL_DNA"] -->|"activates"| CGAS["CGAS"]
    MTDNA["MTDNA"] -->|"activates"| CGAS["CGAS"]
    TDP43["TDP43"] -->|"activates"| CGAS["CGAS"]
    STING1_1["STING1"] -->|"interacts"| CGAS["CGAS"]
    style CGAS fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1326)

Target	Relation	Type	Str
STING	inhibits	gene	1.00
CGAS-STING	activates	gene	1.00
STING	activates	protein	1.00
CGAS-STING	associated_with	gene	1.00
STING	targets	gene	1.00
Als	activates	disease	1.00
Als	inhibits	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Innate Immunity	regulates	pathway	1.00
MTDNA	activates	gene	1.00
IFN	activates	protein	1.00
Inflammation	inhibits	disease	1.00
Neuroinflammation	activates	disease	1.00
Autoimmune	activates	disease	1.00
Senescence	activates	disease	1.00
Innate Immunity	activates	pathway	1.00
Infection	activates	disease	1.00
Immune Response	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
DNA	activates	gene	1.00
Tumor	activates	disease	1.00
CGAS-STING	inhibits	gene	1.00
Als	regulates	disease	1.00
CGAS-STING	therapeutic_target	gene	1.00
STING	regulates	gene	1.00
Autophagy	regulates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
Immune Response	causes	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Intracellular Dna Sensing	involved_in	process	0.95
Inflammation	regulates	disease	0.95
Aberrant DNA	binds	compound	0.95
STING	activates	protein	0.95
Aging	activates	disease	0.95
2'3'-cGAMP	associated_with	compound	0.95
Lysosome Biogenesis	upregulates	process	0.95
Als	associated_with	disease	0.95
cGAMP	associated_with	protein	0.95
cGAMP	produces	protein	0.95
Tumorigenesis	associated_with	process	0.95
Innate Immune System	involved_in	process	0.95
Intracellular DNA Sensing	mediates	process	0.95
DNA Repair	inhibits	process	0.95
Carcinoma	activates	disease	0.95
Cytosolic DNA	associated_with	biomarker	0.95
Type I Interferon Expression	activates	process	0.95
Infection	regulates	disease	0.95

Incoming (688)

Source	Relation	Type	Str
DNA	activates	protein	1.00
INFLAMMATION	activates	gene	1.00
IRF3	activates	gene	1.00
STING	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
TBK1	activates	gene	1.00
TOLLIP	inhibits	protein	1.00
mitochondrial DNA	activates	protein	1.00
dsDNA	activates	gene	1.00
DSDNA	activates	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
CYTOKINES	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
NLRP3	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
CANCER	activates	gene	1.00
UL21	promotes_degradation_of	protein	0.95
cytosolic DNA	activates	phenotype	0.95
Mitochondrial DNA Release	activates	process	0.95
cytosolic DNA	activates	protein	0.95
MTDNA	activates	protein	0.94
UBE3C	catalyzes_ubiquitination_of	protein	0.93
h-1a34778f	targets	hypothesis	0.90
h-bbe4540f	targets	hypothesis	0.90
mtDNA Release	activates	process	0.90
CGAS	encodes	gene	0.90
UBE3C	modifies	protein	0.90
UL21	inhibits	protein	0.90
Mitochondrial DNA	activates	compound	0.90
STING	activates	gene	0.90
PYROPTOSIS	activates	gene	0.90
NF-ΚB	regulates	gene	0.90
APOPTOSIS	activates	gene	0.90
FERROPTOSIS	activates	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
self-DNA	activates	protein	0.85
self-DNA	activates	gene	0.85
Mitochondrial Dna	activates	compound	0.85
Mitochondrial Dna	activates	compound	0.85
FGF21	inhibits	protein	0.85
APOE	upregulates	gene	0.85
nuclear localization	modulates	phenotype	0.85
Tetrahydroxy Stilbene Glucoside	downregulates	compound	0.85
APOE	upregulates	gene	0.85
Mitochondrial Dna	binds	compound	0.80
PQBP1	activates	gene	0.80
endogenous DNA	activates	gene	0.80
APOE Ε4 ALLELE	upregulates	gene	0.80

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific	0.720	neurodegeneration	What determines the specificity of TDP-4
cGAS-STING Senescence Circuit Disruption	0.691	neurodegeneration	Gene expression changes in aging mouse b
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.660	neuroinflammation	How does chronic cGAS/STING activation d
Astrocyte cGAS/STING Activation Converts Protective into Des	0.580	neuroinflammation	How does chronic cGAS/STING activation d

Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta	0.560	neuroinflammation	How does chronic cGAS/STING activation d
Basal cGAS Derepression as Stratification Biomarker	0.520	neurodegeneration	What determines the specificity of TDP-4
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology	0.460	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
cGAS/STING pathway activation by TDP-43-released mtDNA	exploratory	amyotrophic lateral sclerosis	0.950	0.00	iPSC-derived motor neurons	proposed	N/A

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251]	Tomaskovic I, Prieto-Garcia C, Boskovic	Science	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026

Debates (2)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CGAS in their description or question text