gene

STIM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STIM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

26Outgoing

13Incoming

0Experiments

0Debates

Summary

STIM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, binds, inhibits. Associated with Inflammation, Ms, Multiple Sclerosis. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STIM1
Full Name	Stromal Interaction Molecule 1
Aliases	STIM1 protein
Chromosome	11p15.5
Primary Expression	Widely expressed: Brain, T cells, Muscle, Platelets
Molecular Weight	77 kDa
Amino Acids	685 aa
Pathways	Ferroptosis, Glutamate Signaling, glutamate signaling
UniProt ID	Q13586
NCBI Gene ID	6787
Ensembl ID	ENSG00000167323
OMIM	605854
GeneCards	STIM1
Human Protein Atlas	STIM1
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Stroke, Immunodeficiency, Myopathy
Interactions	AMPK, AND, DRAM1, FERROPTOSIS, GENES, GPX4
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STIM1 — AlphaFold Q13586 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STIM1 — Stromal Interaction Molecule 1

gene · 1217 words

→

STIM1 Protein

protein · 627 words

→

Pathway Diagram

graph TD
    STIM1["STIM1"]
    STING1["STING1"]
    STIM1 -->|"binds"| STING1
    STING["STING"]
    STIM1 -->|"binds"| STING
    STIM1 -->|"inhibits"| STING
    Neurodegeneration{"Neurodegeneration"}
    STIM1 -->|"activates"| Neurodegeneration
    Multiple_Sclerosis{"Multiple Sclerosis"}
    STIM1 -->|"activates"| Multiple_Sclerosis
    Ms{"Ms"}
    STIM1 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    STIM1 -->|"activates"| Inflammation
    STIM1 -->|"activates"| STING
    GPX4["GPX4"]
    STIM1 -->|"activates"| GPX4
    Ferroptosis(["Ferroptosis"])
    STIM1 -->|"activates"| Ferroptosis
    FERROPTOSIS["FERROPTOSIS"]
    STIM1 -->|"activates"| FERROPTOSIS
    Glutamate_Signaling(["Glutamate Signaling"])
    STIM1 -->|"activates"| Glutamate_Signaling
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EXCITOTOXICITY -->|"causes"| STIM1
    GPX4 -->|"activates"| STIM1
    GENES["GENES"]
    GENES -->|"activates"| STIM1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| STIM1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| STIM1
    FERROPTOSIS -->|"activates"| STIM1
    STING -->|"activates"| STIM1
    AND["AND"]
    AND -->|"activates"| STIM1
    style STIM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
STING1	binds	gene	0.90
STING	interacts_with	protein	0.90
STING	binds	protein	0.80
STING	inhibits	protein	0.72
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
AND	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
glutamate signaling	participates_in	pathway	0.60
ULK1	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Glutamate Signaling	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Neuron	activates	cell_type	0.60
Interferon	activates	protein	0.60
STING	activates	gene	0.60
GPX4	activates	gene	0.60
Neuron	expressed_in	cell_type	0.55
GLUTAMATE	activates	concept	0.50
EXCITOTOXICITY	activates	concept	0.50

Incoming (13)

Source	Relation	Type	Str
EXCITOTOXICITY	causes	phenotype	0.64
NEURODEGENERATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
AMPK	activates	gene	0.60
STING	activates	gene	0.60
excitotoxicity	activates	process	0.60
DRAM1	interacts_with	gene	0.60
DRAM1	activates	gene	0.60
GENES	activates	gene	0.60
GPX4	activates	gene	0.60
ORAI1	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity