gene

PTK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

1Hypotheses

0Analyses

21Outgoing

29Incoming

0Experiments

0Debates

Summary

PTK2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with Aging, Cancer, Carcinoma. Connected to 28 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PTK2
Aliases	Page for PTK2 Gene, Page for PTK2 Protein
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	125 kDa
Amino Acids	052 aa
Pathways	MAPK, PI3K
Ensembl ID	ENSG00000169398
GeneCards	PTK2
Human Protein Atlas	PTK2
Central kinase domain	Catalytic domain with tyrosine kinase activity
MAPK/ERK pathway	Regulates cell proliferation and differentiation
PI3K/Akt pathway	Promotes cell survival and metabolic regulation
Rho GTPases	Controls cytoskeletal dynamics and cell migration
p130Cas/FAK	Mechanical signaling and focal adhesion turnover
Associated Diseases	Alzheimer's disease, Cancer, Carcinoma, Tumor
Interactions	AGING, AUTOPHAGY, CANCER, CASP3, CASS4, CDK2
KG Connections	50 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PTK2["PTK2"]
    Aging{"Aging"}
    PTK2 -->|"interacts with"| Aging
    Ms{"Ms"}
    PTK2 -->|"regulates"| Ms
    Cancer{"Cancer"}
    PTK2 -->|"interacts with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    PTK2 -->|"interacts with"| Neurodegeneration
    Carcinoma{"Carcinoma"}
    PTK2 -->|"associated with"| Carcinoma
    PTK2 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    PTK2 -->|"associated with"| Tumor
    Epigenetic(["Epigenetic"])
    PTK2 -->|"regulates"| Epigenetic
    Autophagy(["Autophagy"])
    PTK2 -->|"interacts with"| Autophagy
    Mtor(["Mtor"])
    PTK2 -->|"interacts with"| Mtor
    Glycolysis(["Glycolysis"])
    PTK2 -->|"associated with"| Glycolysis
    neurodegeneration["neurodegeneration"]
    PTK2 -->|"implicated in"| neurodegeneration
    AGING["AGING"]
    AGING -->|"interacts with"| PTK2
    SIRT6["SIRT6"]
    SIRT6 -->|"interacts with"| PTK2
    MTOR["MTOR"]
    MTOR -->|"interacts with"| PTK2
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"interacts with"| PTK2
    SIRT7["SIRT7"]
    SIRT7 -->|"interacts with"| PTK2
    P53["P53"]
    P53 -->|"regulates"| PTK2
    RANK["RANK"]
    RANK -->|"interacts with"| PTK2
    CANCER["CANCER"]
    CANCER -->|"interacts with"| PTK2
    SIRT1["SIRT1"]
    SIRT1 -->|"interacts with"| PTK2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| PTK2
    CDK2["CDK2"]
    CDK2 -->|"interacts with"| PTK2
    YWHAZ["YWHAZ"]
    YWHAZ -->|"associated with"| PTK2
    style PTK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
SRC	activates	gene	0.82
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Mtor	interacts_with	pathway	0.60
Epigenetic	regulates	pathway	0.60
Autophagy	interacts_with	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
Alzheimer's disease	implicated_in	disease	0.60
Wnt signaling	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
SRC	associated_with	gene	0.60
SIRT1	interacts_with	gene	0.60
SIRT7	interacts_with	gene	0.60
Glycolysis	associated_with	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60

Incoming (29)

Source	Relation	Type	Str
ITGAV	interacts_with	gene	0.85
TUBB3	activates	gene	0.75
CASP3	interacts_with	gene	0.70
CASS4	interacts_with	protein	0.60
CANCER	associated_with	gene	0.60
AGING	interacts_with	gene	0.60
SIRT6	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT7	interacts_with	gene	0.60
RANK	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
CDK2	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
P53	regulates	gene	0.60
CANCER	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AKT1	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
PGK1	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
MAPK8	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
YWHAZ	associated_with	gene	0.60
MTOR	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Tau-trafficking GWAS loci define a druggable PTK2B endocytos	0.600	Alzheimer's disease	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTK2 in their description or question text

No additional research found