gene

KLF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

KLF4 (Kruppel-Like Factor 4) is a zinc-finger transcription factor essential for cellular reprogramming, neuroprotection, and neural stem cell maintenance, with implications for Alzheimer's and Parkinson's disease therapy.

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🧬 Gene Info

Gene Symbol	KLF4
Full Name	Kruppel-Like Factor 4
Chromosome	9q31.2
Protein Type	Transcription Factor
Function	Cell cycle control: Represses proliferation genes (c-Myc, cyclin D1) while activating cell cycle inhibitors (p21, p27)
Primary Expression	High in brain, GI tract, endothelial cells
Amino Acids	483 aa
Pathways	Akt, Amyloid, Epigenetic, Neurogenesis, Nf-Kb
UniProt ID	O43474
NCBI Gene ID	9312
Ensembl ID	ENSG00000109576
OMIM	602253
GeneCards	KLF4
Human Protein Atlas	KLF4
Associated Diseases	aging, Atherosclerosis, Inflammation, Ms, neurodegeneration, Senescence
Interactions	AND, APOPTOSIS, App, ARG1, ATG7, ATP2A3
SciDEX Hypotheses	KLF4-Mediated Transcriptional Repression of P2RY12
KG Connections	246 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KLF4 — AlphaFold O43474 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KLF4 Gene

gene · 1210 words

→

Pathway Diagram

flowchart TD
    KLF4["KLF4"] -->|"regulates"| Ms["Ms"]
    KLF4["KLF4"] -->|"regulates"| Inflammation["Inflammation"]
    KLF4["KLF4"] -->|"activates"| Cancer["Cancer"]
    KLF4["KLF4"] -->|"activates"| Tumor["Tumor"]
    KLF4["KLF4"] -->|"associated with"| Stroke["Stroke"]
    KLF4["KLF4"] -->|"associated with"| Ms["Ms"]
    KLF4["KLF4"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
    KLF4["KLF4"] -->|"expressed in"| Aging["Aging"]
    KLF4["KLF4"] -.->|"inhibits"| Ms["Ms"]
    KLF4["KLF4"] -->|"biomarker for"| Aging["Aging"]
    KLF4["KLF4"] -->|"activates"| Senescence["Senescence"]
    KLF4["KLF4"] -->|"activates"| Cardiovascular["Cardiovascular"]
    style KLF4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (161)

Target	Relation	Type	Str
BIG1	regulates	gene	0.95
ATP2A3	binds	gene	0.95
ATP2A3	activates	gene	0.95
iPSC Reprogramming	involved_in	process	0.95
Embryonic Stem Cells	expressed_in	cell_type	0.90
Pluripotency	activates	phenotype	0.90
Pluripotency	associated_with	process	0.90
Cellular Senescence	associated_with	process	0.85
Transcription	regulates	process	0.85
Neuro-inflammation	mediates	process	0.80
Resilience	downregulates	phenotype	0.75
Tumor	activates	disease	0.75
Aging	expressed_in	disease	0.75
SOX2	regulates	gene	0.70
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
Ms	inhibits	disease	0.65
Aging	biomarker_for	disease	0.65
Senescence	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
ALS	regulates	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Inflammation	activates	disease	0.65
NCF2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TAU	regulates	gene	0.60
neurodegeneration	associated_with	disease	0.60
MICRORNAS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
AND	regulates	gene	0.60
Autophagy	activates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
NEURODEGENERATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60

Incoming (85)

Source	Relation	Type	Str
SOX2	interacts_with	gene	0.90
PI3K	therapeutic_target	gene	0.70
AGING	expressed_in	gene	0.70
OCT4	regulates	gene	0.70
FOXO3	activates	gene	0.60
FOS	associated_with	gene	0.60
MYC	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
OCT4	activates	gene	0.60
OCT4	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
SOX2	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60
SOX2	regulates	gene	0.60
DNA	activates	gene	0.60
TAU	regulates	gene	0.60
DEPTOR	regulates	gene	0.60
DUSP9	activates	gene	0.60
GFAP	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ROS	activates	gene	0.60
TNF-Α	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
GENES	regulates	gene	0.60
TNF	regulates	gene	0.60
GAIN	regulates	gene	0.60
AKT	regulates	gene	0.60
PI3K	regulates	gene	0.60
FOS	inhibits	gene	0.60
RELA	inhibits	gene	0.60
MYC	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
CLOCK	associated_with	gene	0.60
PPAR	therapeutic_target	gene	0.60
ARG1	activates	gene	0.60
TNF	activates	gene	0.60
NOS2	activates	gene	0.60
SQSTM1	activates	gene	0.60
ATG7	activates	gene	0.60
PPARG	activates	gene	0.60
PARKIN	regulates	gene	0.60
PINK1	regulates	gene	0.60
LC3	regulates	gene	0.60
C-MYC	biomarker_for	gene	0.60
AGING	regulates	gene	0.60
NANOG	regulates	gene	0.60
DAX1	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons
KLF4-Mediated Transcriptional Repression of P2RY12	0.440	neurodegeneration	What determines P2RY12 receptor expressi

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KLF4 in their description or question text

No additional research found