concept

CALCIUM HOMEOSTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

12Outgoing

30Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CALCIUM HOMEOSTASIS

Pathway Diagram

graph TD
    CALCIUM_HOMEOSTASIS["CALCIUM HOMEOSTASIS"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neurite_Outgrowth["Neurite Outgrowth"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptogenesis["Synaptogenesis"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Survival["Neuronal Survival"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Dysfunction["Synaptic Dysfunction"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Degeneration["Neuronal Degeneration"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Transmission["Synaptic Transmission"]
    CALCIUM_HOMEOSTASIS -->|"component_of"| Lysosomal_Functions["Lysosomal Functions"]
    Mitochondria["Mitochondria"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SERCA3["SERCA3"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    PSEN1["PSEN1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    TRPML1["TRPML1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SNCA["SNCA"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    HTT["HTT"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    Energy_Metabolism["Energy Metabolism"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    ER_Mitochondria_Contacts["ER-Mitochondria Contacts"] -->|"regulates"| CALCIUM_HOMEOSTASIS

Outgoing (12)

Target	Relation	Type	Str
Synaptogenesis	regulates	process	0.95
Neuronal Survival	regulates	process	0.95
Neurite Outgrowth	regulates	process	0.95
Synaptic Plasticity	regulates	process	0.95
Neuronal Degeneration	regulates	phenotype	0.90
Synaptic Dysfunction	regulates	phenotype	0.90
Synaptic Transmission	regulates	process	0.90
AMPK	activates	gene	0.85
Lysosomal Functions	component_of	mechanism	0.85
AUTOPHAGY	regulates	process	0.85
Aging	involved_in	process	0.80
Frailty	associated_with	phenotype	0.80

Incoming (30)

Source	Relation	Type	Str
Mitochondria	regulates	cell_type	0.95
SERCA3	regulates	protein	0.95
Mitochondria	involved_in	cell_type	0.95
MCOLN1	regulates	gene	0.90
Amyloid Beta-Peptide	associated_with	compound	0.90
PSEN1	regulates	gene	0.90
TRPML1	regulates	protein	0.90
Oxidative Stress	associated_with	process	0.90
MITOCHONDRIA	regulates	cell_type	0.88
Basal Ganglia Calcifications	associated_with	disease	0.88
CACNA1G	regulates	gene	0.85
SNCA	regulates	gene	0.85
Endoplasmic Reticulum	regulates	organelle	0.85
Energy Metabolism	regulates	process	0.85
ER-Mitochondria Contacts	regulates	process	0.85
ATP2A3	involved_in	gene	0.85
Oxidative Stress	inhibits	process	0.85
Aging	involved_in	process	0.85
HTT	regulates	gene	0.85
Er-Mitochondria Contacts	regulates	process	0.85
endoplasmic reticulum	involved_in	cell_type	0.85
ion pumps	associated_with	protein	0.85
amyloid-beta	associated_with	compound	0.80
AMYLOID-BETA	inhibits	protein	0.80
SNCA	inhibits	protein	0.80
SNCA	modulates	gene	0.80
Urolithin A	modulates	compound	0.80
ANXA11	regulates	gene	0.80
SOD1	regulates	protein	0.75
APOE	regulates	protein	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALCIUM HOMEOSTASIS in their description or question text

No additional research found