| Gene Symbol | REST |
| Full Name | RE1-Silencing Transcription Factor |
| Chromosome | 4q12 |
| Protein Type | Transcription Factor |
| Function | REST (also known as NRSF) is a zinc-finger transcription factor that represses neuronal gene expression in non-neuronal cells and regulates synaptic plasticity in neurons. |
| Pathways | Autophagy, Circadian Rhythm, Epigenetic, Immune Response, Lipid Metabolism |
| UniProt ID | Q9Y2W1 |
| NCBI Gene ID | 5978 |
| Ensembl ID | ENSG00000100647 |
| OMIM | 600571 |
| GeneCards | REST |
| Human Protein Atlas | REST |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Ataxia, Atherosclerosis |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, APOER2, APOPTOSIS |
| SciDEX Hypotheses | REST Complex Dysregulation as Master Epigenetic Sw REST-like neuronal silencing programs suppress MAP |
| KG Connections | 331 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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