concept

NEURONAL DEATH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEURONAL DEATH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

2Hypotheses

3Analyses

4Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	NEURONAL DEATH

Pathway Diagram

graph TD
    NEURONAL_DEATH["NEURONAL DEATH"]
    NEURONAL_DEATH -->|"contributes to"| Brain_Function["Brain Function"]
    Microglia["Microglia"] -->|"causes"| NEURONAL_DEATH
    Apoptosis["Apoptosis"] -->|"causes"| NEURONAL_DEATH
    P53["P53"] -->|"promotes"| NEURONAL_DEATH
    p_tau["p-tau"] -.prevents.-> NEURONAL_DEATH
    ER_stress["ER stress"] -->|"promotes"| NEURONAL_DEATH
    ROS["ROS"] -->|"causes"| NEURONAL_DEATH
    Amyloid_beta["Amyloid-beta"] -->|"causes"| NEURONAL_DEATH
    Viral_and_Microbial_Agents["Viral and Microbial Agents"] -->|"causes"| NEURONAL_DEATH

Outgoing (4)

Target	Relation	Type	Str
Brain Function	contributes_to	phenotype	0.85
brain function	suppresses	phenotype	0.85
Parkinson's Disease	contributes_to	disease	0.85
Brain Function	inhibits	process	0.80

Incoming (66)

Source	Relation	Type	Str
Microglia	causes	cell_type	0.95
P53	promotes	gene	0.95
Apoptosis	causes	process	0.95
p-tau	prevents	protein	0.93
Inflammasome Hyperactivation	contributes_to	process	0.92
ER stress	promotes	process	0.91
ROS	causes	phenotype	0.90
Inflammatory Mediators	contributes_to	protein	0.90
Amyloid-beta	causes	compound	0.90
Viral and Microbial Agents	causes	disease	0.90
Alzheimer'S Disease	causes	disease	0.90
A1 Astrocytes	causes	cell_type	0.90
SQSTM1	protects_against	protein	0.90
FOXO3 nuclear translocation	prevents	process	0.90
Rapamycin	suppresses	drug	0.90
Impaired Autophagy	causes	mechanism	0.90
PANoptosis	causes	process	0.90
Hyperphosphorylated Tau	protects_against	biomarker	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.90
α-Synuclein Aggregation	contributes_to	process	0.90
25172552	leads to	paper	0.90
29066951	triggers	paper	0.90
NEUROTOXIC PROTEINS	causes	protein	0.90
Fragmented Mitochondria	mediates	biomarker	0.90
Neurodegeneration	mediates	process	0.90
Microglia	associated_with	cell_type	0.88
CD47-Blocking Antibody	protects_against	drug	0.88
HK2-PINK1 Pathway	protects_against	pathway	0.88
GPR120	inhibits	receptor	0.87
Phosphorylated MAPT	protects_against	biomarker	0.86
NPM	regulates	protein	0.85
TAU	mediates	protein	0.85
Usp1-Taz-Foxo1 Axis	inhibits	pathway	0.85
FBL	causes	gene	0.85
ASPARAGINE ENDOPEPTIDASE	causes	enzyme	0.85
autophagy dysfunction	promotes	process	0.85
C9ORF72 Hexanucleotide Repeat Expansion	contributes_to	mechanism	0.85
TAU	causes	protein	0.85
Neurodegenerative Diseases	causes	disease	0.85
Neuroinflammation	contributes_to	process	0.85
oxidative_stress	contributes_to	phenotype	0.85
mitochondrial_dysfunction	contributes_to	mechanism	0.85
autophagy dysfunction	contributes_to	phenotype	0.85
Neutrophil Extracellular Traps Formation	contributes_to	process	0.80
blood-spinal cord barrier disruption	contributes_to	process	0.80
LOX1	involved_in	receptor	0.80
BDNF	protects_against	protein	0.80
oxidative stress	causes	process	0.80
AΒ	causes	compound	0.80
Asparagine Endopeptidase	causes	enzyme	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AQP4-Dependent Astrocyte Swelling Exacerbates Excitotoxic Ne	0.670	neurodegeneration	What are the specific molecular mechanis
Paraneoplastic myelopathies involve CD8+ T cell recognition	0.450	neuroinflammation	What are the specific pathophysiological