disease

COPD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COPD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	6 GENES, AMPK, BCL2, BECN1, CTSD, DRP1, FEATURE DEGS, FOXO3
Therapeutic Agents	Anti-Inflammatory Therapy, BYF
KG Connections	309 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    COPD["COPD"] -->|"associated"| Persistent_Cough["Persistent Cough"]
    style Persistent_Cough fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sputum_Production["Sputum Production"]
    style Sputum_Production fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sarcopenia["Sarcopenia"]
    style Sarcopenia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style FRONTOTEMPORAL_DEMENTIA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ROS["ROS"]
    style ROS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    style ENDOPLASMIC_RETICULUM fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Chronic_Inflammation["Chronic Inflammation"] -->|"associated"| COPD["COPD"]
    style Chronic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Neutrophilic_Inflammation["Neutrophilic Inflammation"] -->|"contributes to"| COPD["COPD"]
    style Neutrophilic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"therapeutic target"| COPD["COPD"]
    style STAT3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    HUB_GENES["HUB GENES"] -->|"risk factor for"| COPD["COPD"]
    style HUB_GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Cytokines["Cytokines"] -->|"contributes to"| COPD["COPD"]
    style Cytokines fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style COPD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (170)

Target	Relation	Type	Str
Airflow Limitation	causes	phenotype	0.95
Sputum Production	associated_with	phenotype	0.90
Persistent Cough	causes	phenotype	0.90
Sputum Production	causes	phenotype	0.90
Persistent Cough	associated_with	phenotype	0.90
Als	activates	disease	0.85
Inflammation	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
Als	regulates	disease	0.75
Oxidative Stress	causes	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Sarcopenia	associated_with	disease	0.70
Immune Response	contributes_to	pathway	0.70
Lung Cancer	contributes_to	disease	0.65
Inflammation	causes	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Senescence	therapeutic_target	pathway	0.60
Nf-Κb	causes	pathway	0.60
Senescence	activates	pathway	0.60
Senescence	causes	pathway	0.60
Immune Response	inhibits	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Mapk	inhibits	pathway	0.60
Autophagy	associated_with	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Autophagy	activates	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Epigenetic	contributes_to	pathway	0.60
Mtor	associated_with	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Apoptosis	activates	pathway	0.60
Dysbiosis	implicated_in	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Asthma	contributes_to	disease	0.55
Aging	therapeutic_target	disease	0.55
Als	expressed_in	disease	0.55
Aging	activates	disease	0.55
Als	inhibits	disease	0.55
Cystic Fibrosis	associated_with	disease	0.55
Asthma	regulates	disease	0.55
Aging	inhibits	disease	0.55
Als	associated_with	disease	0.55
PYROPTOSIS	implicated_in	phenotype	0.55
Pulmonary Fibrosis	associated_with	disease	0.55
Fibrosis	associated_with	disease	0.55
Hepatitis	therapeutic_target	disease	0.55
NEUTROPHIL	associated_with	cell_type	0.50

Incoming (260)

Source	Relation	Type	Str
Chronic Inflammation	associated_with	process	0.95
Neutrophilic Inflammation	contributes_to	process	0.95
Byf	treats	drug	0.95
Inflammation	involved_in	process	0.90
STAT3	therapeutic_target	protein	0.90
Hub Genes (9 Novel)	biomarker_for	biomarker	0.90
Hub Genes (2 Genes)	risk_factor_for	biomarker	0.85
INFLAMMATION	therapeutic_target	gene	0.85
HUB GENES	risk_factor_for	gene	0.85
INFLAMMATION	activates	gene	0.85
FEATURE DEGS	causes	gene	0.80
Cytokines	contributes_to	biological_process	0.80
INFLAMMATION	associated_with	gene	0.75
6 GENES	causes	gene	0.75
AKT	inhibits	gene	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
OXIDATIVE STRESS	causes	gene	0.75
INFLAMMATION	regulates	gene	0.75
Anti-Inflammatory Therapy	treats	drug	0.75
CANCER	contributes_to	gene	0.75
PI3K	inhibits	gene	0.75
CHIP	associated_with	disease	0.75
INFLAMMATION	causes	gene	0.75
BYF	treats	drug	0.72
Epigenetic Factors	contributes_to	biological_process	0.70
Protease-Antiprotease Imbalance	contributes_to	biological_process	0.70
CFTR	therapeutic_target	gene	0.65
PER	associated_with	gene	0.65
GPX4	causes	gene	0.65
KEAP1	activates	gene	0.65
FERROPTOSIS	regulates	gene	0.65
NRF2	regulates	gene	0.65
DSDNA	therapeutic_target	gene	0.65
DNA	therapeutic_target	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65
GENES	contributes_to	gene	0.65
SRC	therapeutic_target	gene	0.65
TNF	associated_with	gene	0.65
AKT	therapeutic_target	gene	0.65
MTOR	associated_with	gene	0.65
ESR1	therapeutic_target	gene	0.65
CASP3	therapeutic_target	gene	0.65
AGING	associated_with	gene	0.65
DNA	causes	gene	0.65
PTGS2	therapeutic_target	gene	0.65
PAH	associated_with	gene	0.65
NF-ΚB	causes	gene	0.65
RAGE	therapeutic_target	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
CYTOKINES	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COPD in their description or question text

No additional research found