| Gene Symbol | P67775 |
| Aliases | PP2A |
| Protein Family | Ser/Thr Phosphatase family |
| Protein Type | Serine/Threonine Phosphatase |
| Function | is a major serine/threonine phosphatase that accounts for the majority of cellular phosphatase activity in eukaryotes. |
| Primary Expression | Ubiquitous, high in brain |
| Subcellular Localization | Cytoplasm, nucleus, synapses |
| Molecular Weight | ~36 kDa (catalytic subunit) |
| UniProt ID | [P67775](https://www.uniprot.org/uniprot/P67775) |
| GeneCards | P67775 |
| Human Protein Atlas | P67775 |
| Metal-binding motif | Two metal ions (typically Fe²⁺ and Zn²⁺) coordinated by conserved residues in the active site |
| Active site pocket | Contains the signature motif GDYGHG (residues 124-129) |
| C-terminal tail | Contains a mobile region involved in regulatory interactions |
| B (PPP2R2A) | Neuronal isoform, enriched in brain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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