concept

DONEPEZIL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DONEPEZIL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

No AI portrait yet

💡 Concept Info

Name	DONEPEZIL
Key Genes/Proteins	AKT, APP, CHRNA7
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, COGNITIVE DECLINE, CYTOKINES, EXCITOTOXICITY
Related Pathways	AMPK, AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Donepezil

entity · 2068 words

→

Pathway Diagram

graph TD
    DONEPEZIL["DONEPEZIL"]
    DONEPEZIL -->|"inhibits"| oxidative_stress["oxidative stress"]
    DONEPEZIL -->|"activates"| PP2A["PP2A"]
    DONEPEZIL -->|"binds"| LRPPRC["LRPPRC"]
    DONEPEZIL -->|"inhibits"| Acetylcholine["Acetylcholine"]
    DONEPEZIL -->|"inhibits"| MAPK["MAPK"]
    DONEPEZIL -->|"inhibits"| NF_kB["NF-kB"]
    DONEPEZIL -->|"inhibits"| NLRP3["NLRP3"]
    DONEPEZIL -->|"treats"| Alzheimer_s_disease["Alzheimer's disease"]
    Chinese_herbal_medicine["Chinese herbal medicine"] -->|"interacts"| DONEPEZIL
    CHRNA7["CHRNA7"] -->|"indirectly_activated_by"| DONEPEZIL
    AMPK["AMPK"] -->|"activates"| DONEPEZIL

Outgoing (78)

Target	Relation	Type	Str
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00
Neuroinflammation	downregulates	process	0.95
NLRP3 Inflammasome	associated_with	mechanism	0.90
MAPK Signaling	inhibits	pathway	0.90
STAT3	inhibits	protein	0.85
Alzheimer's Disease	treats	disease	0.85
PP2A	activates	gene	0.80
oxidative stress	inhibits	phenotype	0.80
AMPK	activates	pathway	0.80
COX-2	downregulates	protein	0.80
LRPPRC	binds	gene	0.75
PP2A	activates	protein	0.75
MAPK	inhibits	pathway	0.70
Acetylcholine	associated_with	entity	0.70
NF-kB	inhibits	protein	0.70
NLRP3	inhibits	protein	0.70
AKT	inhibits	protein	0.70
STAT3	inhibits	protein	0.70
NEUROINFLAMMATION	activates	phenotype	0.70
NEUROINFLAMMATION	regulates	phenotype	0.70
Acetylcholine	inhibits	entity	0.70
IL-6	inhibits	protein	0.70
Alzheimer's disease	treats	disease	0.70
CYTOKINES	activates	phenotype	0.65
NEURON	activates	cell_type	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
NEURON	phosphorylates	cell_type	0.65
TAU	phosphorylates	gene	0.65
MEMANTINE	promotes	drug	0.65
NEURON	promotes	cell_type	0.65
NEURONS	promotes	cell_type	0.65
NEURONS	activates	cell_type	0.65
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
COGNITIVE DECLINE	degrades	phenotype	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
AKT	activates	gene	0.65
unfolded protein response	modulates	pathway	0.60
AMPK	activates	gene	0.60
AMPK	promotes	gene	0.60
AMPK	targets	gene	0.60
AKT	targets	gene	0.60
nicotinic receptor	protects_against	receptor	0.60
nicotinic receptor	activates	receptor	0.60
glutamate signaling	modulates	pathway	0.60
PP2A	targets	gene	0.60
PS1	targets	gene	0.60
APP	targets	gene	0.60
LRPPRC	targets	gene	0.60
STAT3	targets	gene	0.55

Incoming (22)

Source	Relation	Type	Str
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00
Chinese herbal medicine	interacts_with	drug	0.70
CHRNA7	indirectly_activated_by	gene	0.70
Acetylcholine	associated_with	entity	0.70
APP	regulates	gene	0.65
APP	treats	gene	0.65
CHOLINERGIC	promotes	cell_type	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.50
AMPK	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
AMPK PATHWAY	associated_with	pathway	0.45
RESVERATROL	associated_with	drug	0.45
GLUTAMATE EXCITOTOXICITY	associated_with	phenotype	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
RIVASTIGMINE	associated_with	drug	0.45
GALANTAMINE	associated_with	drug	0.45
AMPK	activates	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity