protein 2,978 words KG: PP2A
Contents

PP2A Protein

🔬 Protein Info
Gene SymbolPP2A
Full NameProtein Phosphatase 2 Scaffold Subunit A Alpha
AliasesPPP2R1A
Chromosome19q13.41
Protein TypeProtein
Subcellular Localization, and biological function 2. In the healthy brain, PP2A continuously
Molecular Weight65 kDa
PathwaysWnt, Notch pathway, mTOR, mtor, Wnt signaling
UniProt IDP30153
NCBI Gene ID5518
Ensembl IDENSG00000114825
OMIM605983
GeneCardsPP2A
Human Protein AtlasPP2A
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, disease, neurodegeneration
Known Drugs/Compoundsdonepezil, Donepezil, DONEPEZIL, metformin, rapamycin, resveratrol
InteractionsAKT, AKT1, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1
KG Connections343 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (16)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
VCP-Mediated Autophagy Enhancement
Score: 0.59
CYP46A1 Overexpression Gene Therapy
Score: 0.98
Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (14)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

ATR Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: activates
AMBRA1 Gene
gene · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

GAIN inhibits PP2A
PP2A associated_with STAR
STAR associated_with PP2A
PP2A inhibits GAIN
RCAN1 associated_with PP2A
TNF activates PP2A
PI3K associated_with PP2A
PP2A activates ERK1
PP2A activates NRF2
PP2A activates KEAP1

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