gene

FGF19

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF19: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

40Outgoing

7Incoming

0Experiments

0Debates

Summary

Gene profile: FGF19 - a metabolic FGF that regulates bile acid homeostasis, glucose metabolism, and energy expenditure via FGFR4

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🧬 Gene Info

Gene Symbol	FGF19
Full Name	Fibroblast Growth Factor 19
Aliases	Gene profile: FGF19
Chromosome	11q13.1
Function	Unlike the canonical FGFs (FGF1-FGF10), these metabolic FGFs have low heparin-binding affinity, allowing them to enter circulation.
Primary Expression	the small intestine (ileum), particularly in enterocytes 2
Pathways	MAPK pathway, PI3K, MAPK
UniProt ID	Q9KUM4
NCBI Gene ID	2259
Ensembl ID	ENSG00000162337
GeneCards	FGF19
Human Protein Atlas	FGF19
Associated Diseases	Als, Leukemia, Ms
KG Connections	47 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF19 — AlphaFold Q9KUM4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FGF19 — Fibroblast Growth Factor 19

gene · 1001 words

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Pathway Diagram

graph TD
    FGF19["FGF19"]
    Fibrosis{"Fibrosis"}
    FGF19 -->|"therapeutic target"| Fibrosis
    Hepatitis{"Hepatitis"}
    FGF19 -->|"therapeutic target"| Hepatitis
    Als{"Als"}
    FGF19 -->|"therapeutic target"| Als
    Cirrhosis{"Cirrhosis"}
    FGF19 -->|"therapeutic target"| Cirrhosis
    Inflammation{"Inflammation"}
    FGF19 -->|"therapeutic target"| Inflammation
    Aging{"Aging"}
    FGF19 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    FGF19 -->|"therapeutic target"| Ms
    Depression{"Depression"}
    FGF19 -->|"regulates"| Depression
    FGF19 -->|"regulates"| Ms
    FGF19 -->|"associated with"| Als
    FGF19 -->|"associated with"| Ms
    Leukemia{"Leukemia"}
    FGF19 -->|"associated with"| Leukemia
    FGF21["FGF21"]
    FGF21 -->|"therapeutic target"| FGF19
    PI3K["PI3K"]
    PI3K -->|"regulates"| FGF19
    CTSD["CTSD"]
    CTSD -->|"regulates"| FGF19
    ERK["ERK"]
    ERK -->|"associated with"| FGF19
    JAK["JAK"]
    JAK -->|"associated with"| FGF19
    LGALS3["LGALS3"]
    LGALS3 -->|"associated with"| FGF19
    PI3K -->|"associated with"| FGF19
    style FGF19 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
Diabetes	therapeutic_target	disease	0.65
Atherosclerosis	regulates	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Type 2 Diabetes	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Depression	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Pi3K	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Blood-Brain Barrier	regulates	pathway	0.60
APOPTOSIS	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
Jak-Stat	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Pi3K	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Calcium Signaling	regulates	pathway	0.60
Cholesterol	regulates	pathway	0.60
Akt	regulates	pathway	0.60
AKT	regulates	gene	0.60
CTSD	regulates	gene	0.60
PLAU	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
NME1	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
SPP1	associated_with	gene	0.60
FTL	associated_with	gene	0.60
APOE	therapeutic_target	gene	0.60

Incoming (7)

Source	Relation	Type	Str
ERK	associated_with	gene	0.60
JAK	associated_with	gene	0.60
FGF21	therapeutic_target	gene	0.60
LGALS3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
PI3K	regulates	gene	0.60
CTSD	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF19 in their description or question text

No additional research found