Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KL |
| Full Name | Klotho |
| Chromosome | 13q12.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 130 kDa |
| Pathways | oxidative stress response |
| UniProt ID | Q9UEF4 |
| NCBI Gene ID | 9365 |
| Ensembl ID | ENSG00000133116 |
| OMIM | 604824 |
| GeneCards | KL |
| Human Protein Atlas | KL |
| Associated Diseases | Cardiovascular Disease, Chronic Kidney Disease, Neurodegeneration |
| Known Drugs/Compounds | Curcumin, Sulforaphane, Vitamin D |
| Interactions | ADRA2A, BDNF, CX3CL1, CXCL10, ESR2, FGF21 |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KL["KL"]
Frailty["Frailty"]
KL -->|"biomarker for"| Frailty
Endothelial_Cell_Senescence["Endothelial Cell Senescence"]
KL -->|"modulates"| Endothelial_Cell_Senescence
oxidative_stress_response["oxidative stress response"]
KL -->|"participates_in"| oxidative_stress_response
PGRN["PGRN"]
KL -->|"activates"| PGRN
PLAU["PLAU"]
KL -->|"activates"| PLAU
VIM["VIM"]
KL -->|"activates"| VIM
neurodegeneration["neurodegeneration"]
KL -->|"implicated in"| neurodegeneration
BDNF["BDNF"]
BDNF -->|"activates"| KL
CX3CL1["CX3CL1"]
CX3CL1 -->|"activates"| KL
CXCL10["CXCL10"]
CXCL10 -->|"activates"| KL
FGF21["FGF21"]
FGF21 -->|"activates"| KL
FGF23["FGF23"]
FGF23 -->|"activates"| KL
FNDC5["FNDC5"]
FNDC5 -->|"activates"| KL
style KL fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Frailty | biomarker_for | phenotype | 0.95 |
| Kidney | expressed_in | cell_type | 0.95 |
| Brain | expressed_in | brain_region | 0.95 |
| Cardiovascular Disease | implicated_in | disease | 0.90 |
| Chronic Kidney Disease | implicated_in | disease | 0.90 |
| Neurodegeneration | implicated_in | disease | 0.90 |
| PI3K/AKT | modulates | pathway | 0.85 |
| IGF-1 | modulates | gene | 0.85 |
| Endothelial Cell Senescence | modulates | process | 0.85 |
| FGF23 | interacts_with | gene | 0.80 |
| Dietary Inflammatory Index | correlates_with | biomarker | 0.80 |
| VIM | activates | gene | 0.60 |
| PLAU | activates | gene | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| PGRN | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Magnesium | upregulates | compound | 0.75 |
| Vitamin D | modulates | compound | 0.75 |
| Sulforaphane | modulates | compound | 0.75 |
| Curcumin | modulates | compound | 0.75 |
| BDNF | activates | gene | 0.60 |
| CX3CL1 | activates | gene | 0.60 |
| CXCL10 | activates | gene | 0.60 |
| FGF21 | activates | gene | 0.60 |
| FGF23 | activates | gene | 0.60 |
| FNDC5 | activates | gene | 0.60 |
| ADRA2A | inhibits | gene | 0.60 |
| ESR2 | activates | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| GDF15 | activates | gene | 0.60 |
| AGER | associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, | 0.730 | biomarkers | What biomarkers can reliably detect micr |
| CSF YKL-40 as a Priming-Specific Chitinase Marker | 0.710 | biomarkers | What biomarkers can reliably detect micr |
| Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti | 0.540 | neurodegeneration | epigenetic reprogramming aging neurons |
| Targeted DNA Demethylation at the Klotho Locus via dCas9-TET | 0.510 | neurodegeneration | epigenetic reprogramming aging neurons |
| KLF4-Mediated Transcriptional Repression of P2RY12 | 0.440 | neurodegeneration | What determines P2RY12 receptor expressi |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning KL in their description or question text
No additional research found