concept

GDF15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GDF15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

1Hypotheses

1Analyses

41Outgoing

20Incoming

0Experiments

1Debates

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💡 Concept Info

Name	GDF15
Key Genes/Proteins	AMPK, BACE1, BDNF, BMPR1A, CX3CL1, CXCL10
Related Diseases	autophagy, body weight, Body Weight, cancer, cardiovascular disease
Related Pathways	blood-brain barrier
Linked Hypotheses	1 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

GDF15/GDF11 Signaling in Neurodegeneration

mechanism · 1134 words

→

Pathway Diagram

graph TD
    GDF15[GDF15]
    GDF15 -.biomarker for.-> Frailty[Frailty]
    GDF15 -->|downregulates| Body_Weight[Body Weight]
    GDF15 -->|risk_factor_for| Dementia_Risk[Dementia Risk]
    GDF15 -->|activates| BDNF[BDNF]
    GDF15 -->|causes| hepatocellular_carcinoma[hepatocellular carcinoma]
    GDF15 -->|activates| BDNF_NEURONS[BDNF NEURONS]
    GDF15 -->|contributes to| neurodegeneration[neurodegeneration]
    GDF15 -->|mediates| neuroprotection[neuroprotection]
    GDF15 -->|participates in| oxidative_stress_response[oxidative stress response]
    hepatic_stellate_cells[hepatic stellate cells] -->|produces| GDF15
    Metformin[Metformin] -->|upregulates| GDF15
    autophagy[autophagy] -->|regulates| GDF15
    BMPR1A[BMPR1A] -->|interacts| GDF15
    BDNF -->|activates| GDF15
    CX3CL1[CX3CL1] -->|activates| GDF15
    CXCL10[CXCL10] -->|activates| GDF15
    FGF21[FGF21] -->|activates| GDF15
    FGF23[FGF23] -->|activates| GDF15
    FNDC5[FNDC5] -->|activates| GDF15

Outgoing (41)

Target	Relation	Type	Str
h-8ef10f60b8	targeted_by	hypothesis	1.00
Frailty	biomarker_for	phenotype	0.95
Body Weight	downregulates	phenotype	0.90
body weight	associated_with	phenotype	0.85
Frailty	biomarker_for	phenotype	0.85
Dementia Risk	risk_factor_for	phenotype	0.85
BDNF	activates	protein	0.85
hepatocellular carcinoma	causes	disease	0.80
BDNF NEURONS	activates	cell_type	0.80
neuroprotection	mediates	process	0.75
neurodegeneration	contributes_to	process	0.75
oxidative stress response	participates_in	pathway	0.70
GFRAL	expressed_in	gene	0.60
GLP1R	expressed_in	gene	0.60
KL	activates	gene	0.60
PLAU	activates	gene	0.60
VIM	activates	gene	0.60
cancer	implicated_in	disease	0.60
cardiovascular disease	implicated_in	disease	0.60
cancer	regulates	disease	0.60
GDNF	associated_with	gene	0.60
GFRAL	associated_with	gene	0.60
GFRAL	interacts_with	gene	0.60
MMP1	interacts_with	gene	0.60
TFEB	inhibits	gene	0.60
TFEB	associated_with	gene	0.60
GDNF	interacts_with	gene	0.60
TGF	associated_with	gene	0.60
TFEB	causes	gene	0.60
PGRN	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
diabetes	associated_with	disease	0.60
multiple sclerosis	activates	disease	0.60
diabetes	activates	disease	0.60
senescence	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
endothelial cells	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
GDNF	expressed_in	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (20)

Source	Relation	Type	Str
h-8ef10f60b8	targets	hypothesis	1.00
hepatic stellate cells	produces	cell_type	0.90
Metformin	upregulates	drug	0.85
BMPR1A	interacts_with	gene	0.80
BACE1	regulates	gene	0.80
autophagy	regulates	phenotype	0.80
BACE1	enhances	gene	0.70
CX3CL1	activates	gene	0.60
CXCL10	activates	gene	0.60
FGF21	activates	gene	0.60
FGF23	activates	gene	0.60
FNDC5	activates	gene	0.60
BACE1	activates	gene	0.60
BACE1	associated_with	gene	0.60
FGF21	expressed_in	gene	0.60
h-527d32c9	biomarker_target	hypothesis	0.60
BDNF	activates	gene	0.60
AMPK	activates	gene	0.60
metformin	targets	drug	0.60
BDNF	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator	0.653	molecular biology	What is the optimal therapeutic window t

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.583

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

Related Research

Hypotheses and analyses mentioning GDF15 in their description or question text

No additional research found