gene 2,967 words KG: PLAU
Contents

PLAU Gene (Urokinase)

🧬 Gene Info
Gene SymbolPLAU
AliasesuPA, urokinase, ATF
Chromosome10q22.2
Protein TypeProtease
Functionis a gene encoding a secreted serine protease that plays critical roles in fibrinolysis, extracellular matrix (ECM) remodeling, and cell migration.
Molecular Weight54 kDa
Amino Acids411 aa
Exons11
PathwaysTGF-β
UniProt IDP00750
NCBI Gene ID5328
GeneCardsPLAU
Human Protein AtlasPLAU
Associated DiseasesAls, Alzheimer, Leukemia, Ms
InteractionsACE, ACE2, ALZHEIMER, AND, BACE1, Bdnf
KG Connections175 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.92
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (14)

Apoptosis in Neurodegeneration
entity · KG edge: biomarker_for
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
BACE1 (Redirect)
redirect · KG edge: associated_with
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: biomarker_for
ACE Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FGF21 activates PLAU
APP biomarker_for PLAU
FNDC5 activates PLAU
S100B biomarker_for PLAU
PLAU activates CXCL10
PLAU biomarker_for C1Q
PLAU activates CX3CL1
PLAU activates VIM
PLAU activates BDNF
PLAU biomarker_for TGM2

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