gene

NME1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NME1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

22Outgoing

19Incoming

0Experiments

0Debates

Summary

NME1 encodes nucleoside diphosphate kinase 1, involved in nucleotide metabolism, mitochondrial function, and neuronal survival. Associated with neurodegeneration and cancer metastasis.

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🧬 Gene Info

Gene Symbol	NME1
Full Name	NME/Nucleoside Diphosphate Kinase 1
Aliases	Page for NME1 Protein
Chromosome	17q21.33
Protein Type	Enzyme
Function	is a ubiquitous enzyme that catalyzes the transfer of phosphate groups between nucleoside diphosphates (NDPs) and nucleoside triphosphates (NTPs).
Primary Expression	most human tissues:
Molecular Weight	17 kDa
Amino Acids	152 aa
UniProt ID	[P15531](https://www.uniprot.org/uniprot/P15531)
Ensembl ID	ENSG00000214021
GeneCards	NME1
Human Protein Atlas	NME1
N-terminal domain	Contains the phosphate-binding loop (P-loop) motif essential for nucleotide binding
Active site	His-118 serves as the central histidine residue mediating phosphate transfer
Associated Diseases	Als, Leukemia, Ms
Interactions	ASH1L, CAV1, RELN
KG Connections	41 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NME1 - NME Nucleoside Diphosphate Kinase 1

gene · 1370 words

→

NME1 Protein - Nucleoside Diphosphate Kinase 1

protein · 603 words

→

Pathway Diagram

graph TD
    NME1["NME1"]
    Als{"Als"}
    NME1 -->|"associated with"| Als
    Ms{"Ms"}
    NME1 -->|"associated with"| Ms
    Leukemia{"Leukemia"}
    NME1 -->|"associated with"| Leukemia
    CACNA1E["CACNA1E"]
    NME1 -->|"therapeutic target"| CACNA1E
    CACNA2D3["CACNA2D3"]
    NME1 -->|"therapeutic target"| CACNA2D3
    PRKAB1["PRKAB1"]
    NME1 -->|"therapeutic target"| PRKAB1
    CHRNA2["CHRNA2"]
    NME1 -->|"therapeutic target"| CHRNA2
    CNR1["CNR1"]
    NME1 -->|"therapeutic target"| CNR1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    NME1 -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    NME1 -->|"therapeutic target"| EPAS1
    CTSD["CTSD"]
    NME1 -->|"therapeutic target"| CTSD
    CEBPA["CEBPA"]
    NME1 -->|"therapeutic target"| CEBPA
    ASH1L["ASH1L"]
    ASH1L -->|"activates"| NME1
    EPAS1 -->|"therapeutic target"| NME1
    CACNG6["CACNG6"]
    CACNG6 -->|"therapeutic target"| NME1
    BIN1["BIN1"]
    BIN1 -->|"therapeutic target"| NME1
    CHRNA2 -->|"therapeutic target"| NME1
    CEBPA -->|"therapeutic target"| NME1
    GENES["GENES"]
    GENES -->|"therapeutic target"| NME1
    CNR1 -->|"therapeutic target"| NME1
    CTSD -->|"therapeutic target"| NME1
    ERK["ERK"]
    ERK -->|"associated with"| NME1
    JAK["JAK"]
    JAK -->|"associated with"| NME1
    LGALS3["LGALS3"]
    LGALS3 -->|"associated with"| NME1
    style NME1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Akt	associated_with	pathway	0.60
APOPTOSIS	associated_with	gene	0.60
Pi3K	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Jak-Stat	associated_with	pathway	0.60
CACNA1E	therapeutic_target	gene	0.60
CACNA2D3	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
HSP90AA1	associated_with	gene	0.60
SPP1	associated_with	gene	0.60
FTL	associated_with	gene	0.60
RELN	targets	gene	0.60
RELN	interacts_with	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
EPAS1	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
CEBPA	therapeutic_target	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60

Incoming (19)

Source	Relation	Type	Str
ASH1L	activates	gene	0.80
CACNG6	therapeutic_target	gene	0.60
BIN1	therapeutic_target	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CEBPA	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
CAV1	targets	gene	0.60
CAV1	interacts_with	gene	0.60
ERK	associated_with	gene	0.60
EPAS1	therapeutic_target	gene	0.60
JAK	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
FGF19	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NME1 in their description or question text

No additional research found