concept

PGR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections
0Hypotheses
0Analyses
5Outgoing
8Incoming
0Experiments
0Debates

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💡 Concept Info
NamePGR
Key Genes/ProteinsAR, CNR1, ESR1, GRIK1, MAPK10, MAPT
Related DiseasesTriple-Negative Breast Cancer
Related PathwaysMAPK signaling, oxidative stress response

Wiki Pages (4)

Knowledge base pages for this entity

Progranulin Protein (PGRN)

protein · 1828 words

Progranulin (PGRN)

protein · 1536 words

Progranulin (PGRN) - Biomarker

biomarker · 1231 words

PGRMC1 Protein

protein · 528 words

Pathway Diagram

graph TD
    PGR[PGR]
    PGR -.biomarker for.-> Triple_Negative_Breast_Cancer[Triple-Negative Breast Cancer]
    PGR -->|interacts| PIK3R1[PIK3R1]
    PGR -->|participates in| oxidative_stress_response[oxidative stress response]
    PGR -->|participates in| MAPK_signaling[MAPK signaling]
    PGR -->|data_in| benchmark_ot_ad_answer_key_PGR[benchmark_ot_ad_answer_key:PGR]
    AR[AR] -->|interacts| PGR
    CNR1[CNR1] -->|interacts| PGR
    GRIK1[GRIK1] -->|interacts| PGR
    MAPK10[MAPK10] -->|interacts| PGR
    MAPT[MAPT] -->|interacts| PGR
    ESR1[ESR1] -.protects against.-> PGR
    NR3C1[NR3C1] -.protects against.-> PGR
    benchmark_ot_ad_answer_key_PGR -->|data_in| PGR

Outgoing (5)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:PGRdata_indataset_row0.00
Triple-Negative Breast Cancerbiomarker_fordisease0.85
PIK3R1interacts_withgene0.60
oxidative stress responseparticipates_inpathway0.60
MAPK signalingparticipates_inpathway0.60

Incoming (8)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:PGRdata_indataset_row0.00
ESR1protects_againstgene0.60
NR3C1protects_againstgene0.60
ARinteracts_withgene0.60
CNR1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PGR in their description or question text

No additional research found