gene

GRIK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

9Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for GRIK1 - Glutamate Receptor Kainate Type Subunit 1

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🧬 Gene Info

Gene Symbol	GRIK1
Full Name	Glutamate Receptor Kainate Type Subunit 1
Aliases	Page for GRIK1, Page for GRIK1 Protein
Chromosome	21q22.11
Protein Type	Receptor
Function	GRIK1 encodes the GluR5 kainate receptor subunit, which combines with other subunits (GRIK2, GRIK3, GRIK4, GRIK5) to form functional kainate receptors:
Molecular Weight	103 kDa
Amino Acids	889 aa
UniProt ID	P39086
NCBI Gene ID	2898
Ensembl ID	ENSG00000171189
OMIM	138246
GeneCards	GRIK1
Human Protein Atlas	GRIK1
Associated Diseases	neurodegeneration
Interactions	AR, CNR1, MAPK10, MAPT, PGR, PIK3R1
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRIK1 — AlphaFold P39086 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRIK1["GRIK1"]
    Als{"Als"}
    GRIK1 -->|"interacts with"| Als
    Aging{"Aging"}
    GRIK1 -->|"interacts with"| Aging
    Ms{"Ms"}
    GRIK1 -->|"interacts with"| Ms
    Autism{"Autism"}
    GRIK1 -->|"interacts with"| Autism
    neurodegeneration["neurodegeneration"]
    GRIK1 -->|"implicated in"| neurodegeneration
    KCNJ3["KCNJ3"]
    KCNJ3 -->|"associated with"| GRIK1
    style GRIK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Autism	interacts_with	disease	0.65
MAPK signaling	participates_in	pathway	0.60
MAPK10	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PGR	interacts_with	gene	0.60
PIK3R1	interacts_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
genes-grik1	linked_to	wiki	1.00
KCNJ3	associated_with	gene	0.60
AR	interacts_with	gene	0.60
CNR1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIK1 in their description or question text

No additional research found