| Gene Symbol | PIK3R1 |
| Full Name | Phosphoinositide-3-Kinase Regulatory Subunit 1 |
| Aliases | PIK3R1 p85α regulatory subunit of PI3K |
| Chromosome | 5q13.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | Cytoplasm, plasma membrane, endosomes | |
| Molecular Weight | 85 kDa |
| Amino Acids | 724 aa |
| Pathways | PI3K, mTOR, mtor, PI3K pathway |
| GeneCards | PIK3R1 |
| Human Protein Atlas | PIK3R1 |
| Molecular weight | ~85 kDa |
| Isoforms | p85α, p55α (pik3r1 splice variant), p50α |
| Post-translational modifications | Phosphorylation (Y459, Y467), ubiquitination |
| PI3K/Akt pathway | Major downstream effector of p85α-regulated PI3K |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Fibrosis |
| Interactions | AGING, Akt, AKT, AKT1, ALZHEIMER, ANGPT1 |
| KG Connections | 367 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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