| Gene Symbol | NLRP12 |
| Full Name | NLR Family Pyrin Domain Containing 12 |
| Aliases | NLRP12PROTEIN |
| Protein Type | Receptor |
| Function | is a member of the NOD-like receptor (NLR) family that functions primarily as a negative regulator of innate immune signaling. |
| Primary Expression | myeloid cells (monocytes, macrophages, neutrophils) and is present in brain microglia, positioning it to mo |
| Pathways | NF-κB, NF-κB signaling |
| Ensembl ID | ENSG00000142405 |
| GeneCards | NLRP12 |
| Human Protein Atlas | NLRP12 |
| LRR Domain (amino acids 595-753) | The C-terminal leucine-rich repeats function as ligand-sensing modules, detecting microbial products, stress signals, and endogenous danger signals. |
| Inflammasome Formation | Although NLRP12 can form inflammasome complexes, its inflammasome activity is less characterized than that of NLRP3. |
| Immune Cell Modulation | NLRP12 modulates macrophage and dendritic cell responses, regulating cytokine production, antigen presentation, and cell survival. |
| Host Defense | NLRP12 participates in recognition of bacterial pathogens and contributes to host defense against microbial infections. |
| Associated Diseases | Autoimmune |
| Interactions | AIM2, AND, APOPTOSIS, CARD8, Caspase, Cytokine |
| KG Connections | 84 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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