gene

NLRP12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

NLRP12 is an NLR family protein that negatively regulates NF-kB and forms inflammasomes in myeloid cells. Expressed in brain microglia, it modulates neuroinflammatory responses.

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🧬 Gene Info

Gene Symbol	NLRP12
Full Name	NLR Family Pyrin Domain Containing 12
Protein Type	Receptor
Function	is a member of the NOD-like receptor (NLR) family that functions primarily as a negative regulator of innate immune signaling.
Primary Expression	myeloid cells (monocytes, macrophages, neutrophils) and is present in brain microglia, positioning it to mo
Pathways	NF-κB, NF-κB signaling
Ensembl ID	ENSG00000142405
GeneCards	NLRP12
Human Protein Atlas	NLRP12
TRAF2, TRAF6	E3 ubiquitin ligases upstream of NF-κB
ASC	adaptor protein for inflammasome assembly
Caspase-1	effector protease for inflammatory cell death (pyroptosis)
Associated Diseases	Autoimmune
Interactions	AIM2, AND, APOPTOSIS, CARD8, Caspase, Cytokine
KG Connections	84 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NLRP12 — NLR Family Pyrin Domain Containing 12

gene · 631 words

→

NLRP12 Protein — NLR Family Pyrin Domain Containing 12

protein · 617 words

→

Pathway Diagram

graph TD
    NLRP12["NLRP12"]
    Ms{"Ms"}
    NLRP12 -->|"interacts with"| Ms
    NLRP12 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    NLRP12 -->|"therapeutic target"| Cancer
    CYTOKINES["CYTOKINES"]
    NLRP12 -->|"interacts with"| CYTOKINES
    TLR["TLR"]
    NLRP12 -->|"interacts with"| TLR
    AIM2["AIM2"]
    NLRP12 -->|"interacts with"| AIM2
    APOPTOSIS["APOPTOSIS"]
    NLRP12 -->|"interacts with"| APOPTOSIS
    RIPK1["RIPK1"]
    NLRP12 -->|"interacts with"| RIPK1
    ZBP1["ZBP1"]
    NLRP12 -->|"interacts with"| ZBP1
    Apoptosis(["Apoptosis"])
    NLRP12 -->|"interacts with"| Apoptosis
    Innate_Immunity(["Innate Immunity"])
    NLRP12 -->|"interacts with"| Innate_Immunity
    Necroptosis(["Necroptosis"])
    NLRP12 -->|"interacts with"| Necroptosis
    NLRC5["NLRC5"]
    NLRC5 -->|"interacts with"| NLRP12
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"interacts with"| NLRP12
    PYROPTOSIS -->|"therapeutic target"| NLRP12
    style NLRP12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
PANoptosome	forms_complex_in	process	0.95
PANoptosome	component_of	structure	0.95
Autoimmune	implicated_in	disease	0.65
Ms	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
AND	activates	gene	0.60
AND	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
CARD8	activates	gene	0.60
NLRP2	activates	gene	0.60
NLR	interacts_with	gene	0.60
NAD	interacts_with	gene	0.60
Cytokine	interacts_with	protein	0.60
NLRP7	associated_with	gene	0.60
Innate Immunity	implicated_in	pathway	0.60
Inflammasome	activates	pathway	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
IL-18	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
IL-1	interacts_with	gene	0.60
PYROPTOSIS	interacts_with	gene	0.60
Inflammasome	associated_with	pathway	0.60
Caspase	interacts_with	protein	0.60
ZBP1	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
NLRP7	activates	gene	0.60
NLRP1	activates	gene	0.60
GAIN	activates	gene	0.60
NLRP1	associated_with	gene	0.60
NLRP6	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
TLR	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
Innate Immunity	interacts_with	pathway	0.60
Necroptosis	interacts_with	pathway	0.60
Pyroptosis	interacts_with	pathway	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Inflammasome	therapeutic_target	pathway	0.60
Necroptosis	therapeutic_target	pathway	0.60
pyroptosis	participates_in	pathway	0.60
Pyroptosis	therapeutic_target	pathway	0.60
AIM2	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60

Incoming (30)

Source	Relation	Type	Str
AND	activates	gene	0.60
NLRC5	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
PYROPTOSIS	interacts_with	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NLRP10	associated_with	gene	0.60
NLRP1	activates	gene	0.60
NLRP2	activates	gene	0.60
GAIN	implicated_in	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
AIM2	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
ZBP1	interacts_with	gene	0.60
NLRP7	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
NLRP3	activates	gene	0.60
CYTOKINES	interacts_with	gene	0.60
NAD	interacts_with	gene	0.60
TLR	interacts_with	gene	0.60
GAIN	activates	gene	0.60
CARD8	activates	gene	0.60
NLRP10	activates	gene	0.60
NLRP1	co_expressed_with	protein	0.50
CARD8	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLRP12 in their description or question text

No additional research found