protein 740 words KG: NLRP1PROTEIN
Contents

NLRP1 Protein

🔬 Protein Info
Gene SymbolNLRP1
Full NameNLRP1 (NLR Family Pyrin Domain Containing 1)
AliasesNLRP1PROTEIN
Chromosome17p13.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious tissues with highest expression in:
Molecular Weight213 kDa
Amino Acids1839 aa
PathwaysInflammasome, Pyroptosis
UniProt IDQ9Y258
NCBI Gene ID22821
Ensembl IDENSG00000091592
GeneCardsNLRP1
Human Protein AtlasNLRP1
Associated DiseasesAls, Autoimmune, Cancer, Carcinoma, Cardiovascular
Known Drugs/Compoundsrapamycin
InteractionsAGING, AIFM1, AIM2, Akt, AKT, ALZHEIMER
KG Connections355 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
Cerebral Amyloid Angiopathy in Neurodegeneration
mechanism · Pages share 4 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses

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