gene

IFI16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFI16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

10Outgoing

2Incoming

0Experiments

0Debates

Summary

IFI16 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Als, Inflammation, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IFI16
Chromosome	1q23.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	82 kDa
Amino Acids	729 aa
Exons	9
Pathways	Pyroptosis
UniProt ID	IFI16
NCBI Gene ID	3428
GeneCards	IFI16
Human Protein Atlas	IFI16
Associated Diseases	neurodegeneration
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IFI16 Gene

gene · 521 words

→

IFI16 Protein

protein · 1219 words

→

Pathway Diagram

graph TD
    IFI16["IFI16"]
    Als{"Als"}
    IFI16 -->|"regulates"| Als
    Ms{"Ms"}
    IFI16 -->|"regulates"| Ms
    Inflammation{"Inflammation"}
    IFI16 -->|"regulates"| Inflammation
    CARD8["CARD8"]
    IFI16 -->|"associated with"| CARD8
    NLRP1["NLRP1"]
    IFI16 -->|"associated with"| NLRP1
    INFLAMMATION["INFLAMMATION"]
    IFI16 -->|"regulates"| INFLAMMATION
    AIM2["AIM2"]
    IFI16 -->|"associated with"| AIM2
    NLRP3["NLRP3"]
    IFI16 -->|"associated with"| NLRP3
    Inflammasome(["Inflammasome"])
    IFI16 -->|"associated with"| Inflammasome
    Pyroptosis(["Pyroptosis"])
    IFI16 -->|"regulates"| Pyroptosis
    neurodegeneration["neurodegeneration"]
    IFI16 -->|"implicated in"| neurodegeneration
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"regulates"| IFI16
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| IFI16
    style IFI16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
CARD8	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
NLRP3	associated_with	gene	0.60
Inflammasome	associated_with	pathway	0.60
Pyroptosis	regulates	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
PYROPTOSIS	regulates	gene	0.60
HDAC6	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IFI16 in their description or question text

No additional research found