gene

NLRP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

31Outgoing

13Incoming

0Experiments

0Debates

Summary

NLRP2 is a NOD-like receptor protein that forms inflammasome complexes and regulates neuroinflammation in Alzheimer's disease, Parkinson's disease, and epilepsy

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NLRP2
Full Name	NLR Family Pyrin Domain Containing 2
Chromosome	19q13.42
Protein Type	Receptor
Function	is a member of the NOD-like receptor (NLR) family that plays critical roles in innate immunity and inflammasome formation.
Primary Expression	neurons, astrocytes, and microglia, where it participates in t
Molecular Weight	114 kDa
Amino Acids	975 aa
Exons	10
Pathways	Inflammasome, Innate Immunity, pyroptosis
Ensembl ID	ENSG00000163352
GeneCards	NLRP2
Human Protein Atlas	NLRP2
Phosphorylation	Kinases including PKR and CK2 can phosphorylate NLRP2
Ubiquitination	NLRP2 is subject to both K63-linked and linear ubiquitination
Associated Diseases	Autoimmune
Interactions	AND, CARD8, GAIN, NEURODEGENERATIVE DISEASES, NLRP1, NLRP10
KG Connections	44 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NLRP2 — NLR Family Pyrin Domain Containing 2

gene · 1580 words

→

NLRP2 Protein — NLR Family Pyrin Domain Containing 2

protein · 649 words

→

Pathway Diagram

graph TD
    NLRP2["NLRP2"]
    Als{"Als"}
    NLRP2 -->|"expressed in"| Als
    Aging{"Aging"}
    NLRP2 -->|"expressed in"| Aging
    Ms{"Ms"}
    NLRP2 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    NLRP2 -->|"expressed in"| Inflammation
    ASC["ASC"]
    NLRP2 -->|"expressed in"| ASC
    CYTOKINES["CYTOKINES"]
    NLRP2 -->|"expressed in"| CYTOKINES
    INFLAMMATION["INFLAMMATION"]
    NLRP2 -->|"expressed in"| INFLAMMATION
    AIM2["AIM2"]
    NLRP2 -->|"expressed in"| AIM2
    NLRP3["NLRP3"]
    NLRP2 -->|"expressed in"| NLRP3
    Inflammasome(["Inflammasome"])
    NLRP2 -->|"expressed in"| Inflammasome
    Immune_Response(["Immune Response"])
    NLRP2 -->|"expressed in"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NLRP2 -->|"implicated in"| neurodegeneration
    NLRP1["NLRP1"]
    NLRP1 -->|"expressed in"| NLRP2
    style NLRP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
Autoimmune	activates	disease	0.65
Als	expressed_in	disease	0.65
Autoimmune	implicated_in	disease	0.65
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Ms	activates	disease	0.65
NLRP12	activates	gene	0.60
CARD8	activates	gene	0.60
NLRP1	activates	gene	0.60
NLRP3	activates	gene	0.60
PANX1	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
Inflammasome	expressed_in	pathway	0.60
Immune Response	expressed_in	pathway	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
Innate Immunity	implicated_in	pathway	0.60
Inflammasome	activates	pathway	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
ASC	expressed_in	gene	0.60
AIM2	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
GAIN	implicated_in	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
NLRP3	co_expressed_with	protein	0.50
NLRP6	co_expressed_with	gene	0.50

Incoming (13)

Source	Relation	Type	Str
NLRP10	activates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
NLRP1	expressed_in	gene	0.60
NLRP3	activates	gene	0.60
NLRP1	activates	gene	0.60
GAIN	activates	gene	0.60
CARD8	activates	gene	0.60
NLRP6	activates	gene	0.60
NLRP7	activates	gene	0.60
NLRP12	activates	gene	0.60
NLRP1	co_expressed_with	protein	0.50
NLRP12	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLRP2 in their description or question text

No additional research found