| Gene Symbol | RNF186 |
| Full Name | Ring Finger Protein 186 |
| Aliases | RNF186PROTEIN |
| Chromosome | 9q32 |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neuronal tissues where it participates in protein quality control, ER-associated degradation (ERAD), and cellular stress responses |
| Subcellular Localization | - **N-terminal signal peptide**: Targeting to secretory pathway ## Molecular Fu |
| UniProt ID | Q96MC7 |
| GeneCards | RNF186 |
| Human Protein Atlas | RNF186 |
| RING domain | C3HC4-type RING finger for E3 ubiquitin ligase activity |
| Transmembrane region | Single-pass membrane anchor for ER localization |
| N-terminal signal peptide | Targeting to secretory pathway |
| High | Small intestine, colon, stomach |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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