gene

TEAD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TEAD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

19Outgoing

12Incoming

0Experiments

0Debates

Summary

TEAD1 (TEA Domain Transcription Factor 1) is a transcription factor serving as the main effector of the Hippo signaling pathway. It regulates cell proliferation, differentiation, and survival. Implicated in Alzheimer's disease, cancer, and various developmental disorders.

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🧬 Gene Info

Gene Symbol	TEAD1
Full Name	TEA Domain Transcription Factor 1
Chromosome	11p15.4
Protein Type	Transcription Factor
Function	is a member of the TEA domain (TEA/ATTS) transcription factor family.
Amino Acids	426 aa
Exons	16
UniProt ID	P28347
NCBI Gene ID	7003
Ensembl ID	ENSG00000187091
OMIM	189892
GeneCards	TEAD1
Human Protein Atlas	TEAD1
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	Actin, AND, BLM, MITOCHONDRIAL DYSFUNCTION, PRDX3, Ras
KG Connections	31 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TEAD1 — AlphaFold P28347 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TEAD1 — TEA Domain Transcription Factor 1

gene · 3104 words

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Pathway Diagram

graph TD
    TEAD1["TEAD1"]
    Tumor{"Tumor"}
    TEAD1 -->|"therapeutic target"| Tumor
    Ms{"Ms"}
    TEAD1 -->|"therapeutic target"| Ms
    Glioblastoma{"Glioblastoma"}
    TEAD1 -->|"therapeutic target"| Glioblastoma
    EGFR["EGFR"]
    TEAD1 -->|"regulates"| EGFR
    FGFR3["FGFR3"]
    TEAD1 -->|"therapeutic target"| FGFR3
    GENES["GENES"]
    TEAD1 -->|"therapeutic target"| GENES
    NF1["NF1"]
    TEAD1 -->|"therapeutic target"| NF1
    IDH1["IDH1"]
    TEAD1 -->|"therapeutic target"| IDH1
    neurodegeneration["neurodegeneration"]
    TEAD1 -->|"implicated in"| neurodegeneration
    CDK4["CDK4"]
    CDK4 -->|"therapeutic target"| TEAD1
    GENES -->|"therapeutic target"| TEAD1
    EGFR -->|"regulates"| TEAD1
    IDH1 -->|"therapeutic target"| TEAD1
    NF1 -->|"therapeutic target"| TEAD1
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"therapeutic target"| TEAD1
    FGFR3 -->|"therapeutic target"| TEAD1
    AND["AND"]
    AND -->|"regulates"| TEAD1
    style TEAD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
YAP1	interacts_with	protein	0.75
Glioblastoma	therapeutic_target	disease	0.65
Senescence	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
GENES	therapeutic_target	gene	0.60
Epithelial	inhibits	cell_type	0.60
EGFR	regulates	gene	0.60
Ras	inhibits	protein	0.60
FGFR3	therapeutic_target	gene	0.60
NF1	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
Rb	inhibits	protein	0.60
PRDX3	activates	gene	0.60
YAP1	activates	gene	0.60
AND	inhibits	gene	0.60
Actin	activates	protein	0.60
Epithelial Cell	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
MAPK3	regulates	gene	0.85
EGFR	regulates	gene	0.60
IDH1	therapeutic_target	gene	0.60
NF1	therapeutic_target	gene	0.60
FGFR3	therapeutic_target	gene	0.60
YAP1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
CDK4	therapeutic_target	gene	0.60
BLM	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
PRDX3	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TEAD1 in their description or question text

No additional research found