gene 1,827 words KG: NESTIN
Contents

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

🧬 Gene Info
Gene SymbolNESTIN
Chromosome1q23.1
Protein FamilyClass VI intermediate filaments
Functionis a protein encoded by the NES gene.
Primary Expressionneural stem and progenitor cells during development and in adult neurogenic regions[@reynolds1992]:
Subcellular LocalizationCytoplasm, intermediate filaments
Molecular Weight220 kDa
Amino Acids4477 aa
PathwaysCircadian Rhythm, Mapk, Mitochondrial Function, Wnt
UniProt IDP48681
NCBI Gene ID4756
Ensembl IDENSG00000132688
GeneCardsNESTIN
Human Protein AtlasNESTIN
N-terminal head domainHighly charged, involved in protein-protein interactions
Associated DiseasesNeurodevelopmental disorders, Brain tumors, Alzheimer's disease, Parkinson's disease, Stroke
InteractionsAKT, ALDH1L1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ARC
KG Connections164 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Complement C1q Subtype Switching
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67

Related Analyses (3)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (14)

Astrocytes
cell · KG edge: expressed_in
ARC-IM Adaptive Neurostimulation for PD
clinical · KG edge: inhibits
Astrocytes
entity · KG edge: expressed_in
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in
ALDH1L1
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

SOX2 expressed_in NESTIN
EGF expressed_in NESTIN
GFAP expressed_in NESTIN
NESTIN expressed_in ALDH1L1
NESTIN expressed_in NOTCH1
NESTIN expressed_in DLK2
DLK2 expressed_in NESTIN
ALDH1L1 expressed_in NESTIN
NESTIN expressed_in GFAP
NGF activates NESTIN

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