gene

GOT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GOT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

46Outgoing

27Incoming

0Experiments

0Debates

Summary

GOT1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Als, Carcinoma, Fibrosis. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GOT1
Full Name	Glutamic-Oxaloacetic Transaminase 1
Chromosome	10q24.3
Protein Type	Enzyme
Function	Amino acid metabolism — Interconversion of aspartate and glutamate
Molecular Weight	45 kDa
Amino Acids	413 aa
Exons	11
Pathways	Ferroptosis, Proteasome, Ubiquitin-Proteasome
UniProt ID	P17174
NCBI Gene ID	2805
Ensembl ID	ENSG00000163283
OMIM	138150
GeneCards	GOT1
Human Protein Atlas	GOT1
Associated Diseases	Carcinoma, Hepatocellular Carcinoma
Interactions	ACSL4, ACTB, ATG, BECLIN1, BECN1, COL1A1
KG Connections	73 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GOT1 — AlphaFold P17174 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GOT1 Gene

gene · 1853 words

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Pathway Diagram

graph TD
    GOT1["GOT1"]
    Carcinoma{"Carcinoma"}
    GOT1 -->|"associated with"| Carcinoma
    Fibrosis{"Fibrosis"}
    GOT1 -->|"activates"| Fibrosis
    Als{"Als"}
    GOT1 -->|"activates"| Als
    Ms{"Ms"}
    GOT1 -->|"activates"| Ms
    GOT1 -->|"inhibits"| Ms
    SQSTM1["SQSTM1"]
    GOT1 -->|"associated with"| SQSTM1
    GPT["GPT"]
    GOT1 -->|"associated with"| GPT
    ELAVL1["ELAVL1"]
    GOT1 -->|"associated with"| ELAVL1
    GPX4["GPX4"]
    GOT1 -->|"associated with"| GPX4
    ATG["ATG"]
    GOT1 -->|"associated with"| ATG
    BECLIN1["BECLIN1"]
    GOT1 -->|"activates"| BECLIN1
    P62["P62"]
    GOT1 -->|"associated with"| P62
    MIRNAS["MIRNAS"]
    MIRNAS -->|"inhibits"| GOT1
    style GOT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GOT1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ms	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
P62	associated_with	gene	0.60
FTH1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
ACSL4	activates	gene	0.60
TFR1	activates	gene	0.60
GPX4	activates	gene	0.60
GPT	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
PTGS2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TGFB1	interacts_with	gene	0.60
cancer	interacts_with	disease	0.60
ferroptosis	participates_in	pathway	0.60
ATG	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Proteasome	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
GPX4	interacts_with	gene	0.60
GPT	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BECLIN1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
FERROPTOSIS	inhibits	gene	0.60
RNA	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
traumatic brain injury	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
GSH	interacts_with	gene	0.60

Incoming (27)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GOT1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
MIRNAS	inhibits	gene	0.60
COL1A1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ATG	associated_with	gene	0.60
ROS	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
GPX4	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
P62	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
FTH1	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
BECLIN1	activates	gene	0.60
PTGS2	associated_with	gene	0.60
ATG	interacts_with	gene	0.60
COL1A1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ELAVL1	interacts_with	gene	0.60
FTH1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity