concept

FERRITIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERRITIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

1Hypotheses

0Analyses

39Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	FERRITIN

Pathway Diagram

graph TD
    FERRITIN["FERRITIN"]
    FERRITIN -->|"binds"| Iron["Iron"]
    FERRITIN -->|"involved_in"| IRON_METABOLISM["IRON METABOLISM"]
    FERRITIN -->|"regulates"| Ischemia["Ischemia"]
    FERRITIN -->|"regulates"| Als["Als"]
    FERRITIN -->|"regulates"| Cancer["Cancer"]
    FERRITIN -->|"regulates"| Ferroptosis["Ferroptosis"]
    FERRITIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NCOA4["NCOA4"] -->|"mediates"| FERRITIN
    HFE["HFE"] -->|"regulates"| FERRITIN
    TFR1["TFR1"] -->|"regulates"| FERRITIN
    JUN["JUN"] -->|"regulates"| FERRITIN
    MITOCHONDRIA["MITOCHONDRIA"] -->|"regulates"| FERRITIN
    FERROPORTIN["FERROPORTIN"] -->|"regulates"| FERRITIN

Outgoing (39)

Target	Relation	Type	Str
Iron	binds	compound	0.95
Tfr1	binds	receptor	0.90
IRON METABOLISM	involved_in	entity	0.90
Iron Metabolism	involved_in	pathway	0.88
Ferroptosis	contributes_to	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Parkinson	contributes_to	disease	0.60
Ischemia	inhibits	disease	0.60
Ferroptosis	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
Cancer	therapeutic_target	disease	0.60
Diabetes	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Parkinson	activates	disease	0.60
Als	inhibits	disease	0.60
Parkinson	regulates	disease	0.60
Cancer	regulates	disease	0.60
Ferroptosis	regulates	disease	0.60
Ischemia	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Neurodegeneration	regulates	disease	0.60
Als	regulates	disease	0.60
Cardiomyopathy	inhibits	disease	0.60
Cancer	activates	disease	0.60
Ferroptosis	activates	disease	0.60
Autophagy	contributes_to	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Autophagy	degrades	pathway	0.55
Lipid Metabolism	inhibits	pathway	0.55
Autophagy	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Ferroptosis Pathway	therapeutic_target	pathway	0.55
Autophagy	regulates	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Pi3K/Akt	regulates	pathway	0.55
Mtor	regulates	pathway	0.55
Mtor	activates	pathway	0.55
Pi3K/Akt	activates	pathway	0.55

Incoming (59)

Source	Relation	Type	Str
NCOA4	degrades	gene	0.90
NCOA4	mediates	gene	0.90
NCOA4	degrades	entity	0.90
TXB2	associated_with	drug	0.70
6-OHDA	regulates	gene	0.60
DJ-1	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
GSH	inhibits	gene	0.60
LIPOPHAGY	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
LIPOPHAGY	degrades	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
PARKINSON	activates	gene	0.60
HFE	regulates	gene	0.60
TFR1	regulates	gene	0.60
JUN	regulates	gene	0.60
FERROPORTIN	regulates	gene	0.60
DMT1	regulates	gene	0.60
GPX4	regulates	gene	0.60
GPX4/SLC7A11	regulates	gene	0.60
NCOA4	activates	gene	0.60
SLC7A11	regulates	gene	0.60
TFR1	interacts_with	gene	0.60
GPX4	inhibits	gene	0.60
VDR	inhibits	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
SLC7A11	inhibits	gene	0.60
ATG5	activates	gene	0.60
BECN1	regulates	gene	0.60
ATG13	activates	gene	0.60
ATG3	activates	gene	0.60
ATG4B	activates	gene	0.60
ATG7	activates	gene	0.60
NOX1	contributes_to	gene	0.60
IDH1	regulates	gene	0.60
PRMT1	regulates	gene	0.60
NCOA4	regulates	gene	0.60
MTOR	regulates	gene	0.60
SCD1	regulates	gene	0.60
NRF2	regulates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60
MAO	regulates	gene	0.60
ACETYL-COA	regulates	gene	0.60
RNA	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med	0.480	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
S-equol-induced ferroptosis mechanism in TNBC cells	exploratory	Triple negative breast cancer	0.900	0.00	TNBC cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FERRITIN in their description or question text

No additional research found