concept

FERRITINOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERRITINOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

1Hypotheses

1Analyses

14Outgoing

10Incoming

1Experiments

1Debates

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💡 Concept Info

Name	FERRITINOPHAGY
Key Genes/Proteins	NCOA4

Pathway Diagram

graph TD
    FERRITINOPHAGY["FERRITINOPHAGY"]
    FERRITINOPHAGY -->|"modulates"| iron_homeostasis["iron homeostasis"]
    FERRITINOPHAGY -->|"promotes"| oxidative_stress["oxidative stress"]
    FERRITINOPHAGY -->|"causes"| ferroptosis["ferroptosis"]
    FERRITINOPHAGY -->|"contributes to"| Ferroptosis["Ferroptosis"]
    FERRITINOPHAGY -->|"promotes"| reactive_oxygen_species_accumu["reactive oxygen species accumulation"]
    FERRITINOPHAGY -->|"promotes"| inflammation["inflammation"]
    NCOA4["NCOA4"] -->|"mediates"| FERRITINOPHAGY
    ULK1["ULK1"] -->|"activates"| FERRITINOPHAGY
    PI3K_AKT_MTOR["PI3K/AKT/MTOR"] -->|"regulates"| FERRITINOPHAGY
    STAT3["STAT3"] -->|"regulates"| FERRITINOPHAGY
    BECN1["BECN1"] -->|"regulates"| FERRITINOPHAGY

Outgoing (14)

Target	Relation	Type	Str
oxidative stress	promotes	phenotype	0.95
iron homeostasis	modulates	process	0.95
ferroptosis	associated_with	process	0.90
ferroptosis	causes	phenotype	0.90
reactive oxygen species accumulation	promotes	phenotype	0.90
Ferroptosis	contributes_to	process	0.90
Intracellular Iron	associated_with	compound	0.90
inflammation	promotes	process	0.90
Ferroptosis	modulates	process	0.90
Iron Homeostasis	regulates	pathway	0.90
Ferroptosis	involved_in	process	0.85
organ injury	causes	phenotype	0.85
Autophagy	involved_in	process	0.85
ferroptosis	activates	mechanism	0.70

Incoming (10)

Source	Relation	Type	Str
NCOA4	activates	gene	0.95
NCOA4	mediates	gene	0.95
PI3K/AKT/MTOR	regulates	pathway	0.90
NCOA4	regulates	gene	0.90
ULK1	activates	gene	0.90
NCOA4	mediates	gene	0.90
NOX1	associated_with	entity	0.85
STAT3	regulates	protein	0.85
BECN1	regulates	gene	0.85
NCOA4	regulates	gene	0.72

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med	0.480	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
S-equol-induced ferroptosis mechanism in TNBC cells	exploratory	Triple negative breast cancer	0.900	0.00	TNBC cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning FERRITINOPHAGY in their description or question text

No additional research found