gene

OXIDATIVE STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9722Connections

6Hypotheses

7Analyses

50Outgoing

50Incoming

1Experiments

11Debates

Summary

OXIDATIVE STRESS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 3134 entities in the SciDEX knowledge graph.

View on Wiki →

AI-generated illustration · click image to enlarge

Regenerate portrait ↻

🧬 Gene Info

Gene Symbol	OXIDATIVE STRESS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	AFMK, CARBIDOPA, CURCUMIN, DAPAGLIFLOZIN, DIMETHYL FUMARATE, DONEPEZIL
Interactions	6-OHDA, ABCD1, ABCD2, ABCD3, ABCG2, ACC
KG Connections	5104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALS["ALS"]
        SOD1["SOD1"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        P62["P62"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AKT["AKT"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    subgraph Therapeutic["Therapeutic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Als["Als"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Diabetes["Diabetes"]
    end
    subgraph Signaling["Signaling"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Inflammation["Inflammation"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Autophagy["Autophagy"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Epigenetic["Epigenetic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
        AUTOPHAGY_1["AUTOPHAGY"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        APOPTOSIS["APOPTOSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3767)

Target	Relation	Type	Str
PARKIN	activates	gene	1.00
CANCER	causes	gene	1.00
GENES	regulates	gene	1.00
Parkinson	regulates	disease	1.00
Stroke	regulates	disease	1.00
DNA	activates	gene	1.00
Inflammation	inhibits	disease	1.00
Oxidative Phosphorylation	activates	pathway	1.00
LC3	activates	gene	1.00
Fibrosis	inhibits	disease	1.00
Neurodegeneration	regulates	disease	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Tumor	activates	disease	1.00
Inflammation	associated_with	disease	1.00
Ferroptosis	activates	pathway	1.00
INFLAMMATION	associated_with	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Apoptosis	inhibits	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Nf-Κb	inhibits	pathway	1.00
Atherosclerosis	therapeutic_target	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Glycolysis	activates	pathway	1.00
EXERCISE	activates	gene	1.00
SIRT1	activates	gene	1.00
AGING	associated_with	gene	1.00
Cancer	activates	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Tumor	associated_with	disease	1.00
TDP-43 aggregation	promotes	process	1.00
Oxidative Stress	associated_with	pathway	1.00
HO-1	activates	gene	1.00
Mitophagy	regulates	pathway	1.00
NRF2	associated_with	gene	1.00
Cardiovascular	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
APOPTOSIS	activates	gene	1.00
Parkinson	associated_with	disease	1.00
MITOCHONDRIA	associated_with	gene	1.00
Autophagy	associated_with	pathway	1.00
Mitochondrial Function	associated_with	pathway	1.00
Mapk	therapeutic_target	pathway	1.00
Obesity	associated_with	disease	1.00
Tumor	inhibits	disease	1.00
TNF-Α	inhibits	gene	1.00
CANCER	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Cancer	causes	disease	1.00

Incoming (5955)

Source	Relation	Type	Str
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
INFLAMMATION	regulates	gene	1.00
DIABETES MELLITUS	therapeutic_target	gene	1.00
Aging	inhibits	disease	1.00
BCL-2	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
MTDNA	activates	gene	1.00
PI3K	inhibits	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
HO-1	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Fibrosis	therapeutic_target	disease	1.00
BAX	activates	gene	1.00
SIRT1	activates	gene	1.00
KEAP1	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
Als	expressed_in	disease	1.00
KEAP1	regulates	gene	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Stroke	therapeutic_target	disease	1.00
AUTOPHAGY	regulates	gene	1.00
NRF2	activates	gene	1.00
Ischemia	therapeutic_target	disease	1.00
ALS	associated_with	gene	1.00
Neuroinflammation	therapeutic_target	disease	1.00
AMYLOID	associated_with	gene	1.00
PINK1	activates	gene	1.00
NEURODEGENERATION	targets	gene	1.00
Aging	therapeutic_target	disease	1.00
Aging	associated_with	disease	1.00
TAU	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
NRF2	regulates	gene	1.00
PARKINSON	associated_with	gene	1.00
MTOR	activates	gene	1.00
GENES	therapeutic_target	gene	1.00
Parkinson	therapeutic_target	disease	1.00
AGING	associated_with	gene	1.00
AKT	inhibits	gene	1.00
Inflammation	regulates	disease	1.00
GENES	activates	gene	1.00
Diabetes	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
DNA	associated_with	gene	1.00
Senescence	associated_with	disease	1.00
PARKIN	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde	0.700	neurodegeneration	Investigate mechanisms of epigenetic rep
NRF2-Mediated Proteostatic Convergence: Shared Oxidative Str	0.700	neurodegeneration	-
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
NRF2 Activation to Counteract Oxidative Stress from RGS6 Def	0.518	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
XOR+ stress-responsive astrocytes represent a novel AD-assoc	0.380	Alzheimer's disease	-

Astrocyte-specific autophagy deficiency induces NADPH oxidas	0.380	ALS	How do non-cell autonomous effects of au

Mentioning Analyses (7)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
In midlife, lower Aβ42:Aβ40 ratio was associated with increased risk o	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (11)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning OXIDATIVE STRESS in their description or question text

Astrocyte-specific autophagy deficiency induces NADPH oxidase-mediated oxidative

Score: 0.380 · ALS · 2026-04-27

We hypothesize that autophagy dysfunction specifically in astrocytes induces motor neuron toxicity through impaired mito